Abstract Purpose Protein phosphatase 2A (PP2A) is a family of serine/threonine
phosphatases that regulate multiple cellular signalling pathways involved in proliferation …

Abstract Phospholipase C Beta 1 (PLCB1) regulates the abundance of PI (4, 5) P2 in the
plasma membrane and is implicated in various kinds of cancers. This study aimed to …

Metastasis is the leading cause of mortality in breast cancer patients and lysophosphatidate
(LPA) signaling promotes this process. LPA signaling is attenuated by lipid phosphate …

The protein tyrosine phosphatase PTPL1/PTPN13, the activity of which is decreased through
allelic loss, promoter methylation, or somatic mutations in some tumors, has been proposed …

Abstract Estrogen receptor (ER)-negative, progesterone receptor (PR)-negative and HER2-
negative, or “triple negative,” breast cancer (TNBC) is a poor prognosis clinical subtype that …

Breast cancer is the most common type of cancer among American women, and remains the
second leading cause of cancer-related death for female in the United States. It has been …

Aims Recently, studies indicated that inflammation could exacerbate the development of BC.
Karyopherin α-2 (KPNA2) is a molecule which modulates nucleocytoplasmic transport and is …

Introduction The loss of E-cadherin based cell-cell contacts and tumor cell migration to the
vasculature and lymphatic system are hallmarks of metastasis of epithelial cancers. Type I …

Objective: Triple negative breast cancer (TNBC) is known to have aggressive clinical course
and a high risk of recurrence. Given the lack of effective targeted therapy options, paclitaxel …

Metastasis is the major cause of breast cancer mortality. We recently reported that aberrant
G-protein coupled receptor (GPCR) signaling promotes breast cancer metastasis by …