Background The control of breast cell survival is of critical importance for preventing breast
cancer initiation and progression. The activity of many proteins which regulate cell survival is …

Breast cancer is a heterogeneous disease, presenting as several diverse clinical and
histologic varieties and it is now the most frequently diagnosed cancer and is the sixth …

Breast cancer (Bca) remains the most common form of malignancy affecting females in
China, leading to significant reductions in the mental and physical health of those with this …

Pancreatic cancer, as a malignant tumor with a very poor prognosis, has a high mortality. It is
imperative to clarify the mechanism of pancreatic cancer development and find suitable …

Cancer cells take advantage of signaling cascades to meet their requirements for sustained
growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation …

Abstract Atypical Protein Kinase C zeta (PKCζ) forms Partitioning-defective (PAR) polarity
complex for apico-basal distribution of membrane proteins essential to maintain normal …

Abstract Specificity protein 1 (Sp1) is a ubiquitous transcription factor and is highly
expressed in breast cancer. However, its expression pattern and role in breast cancer …

Abstract The p21-activated kinase 4 (PAK4) is sufficient to transform noncancerous
mammary epithelial cells and to form tumors in the mammary glands of mice. The …

Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor
progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival …

Abstract Phospholipases A2 (PLA2s) overexpression is closely associated with the
malignant potential of breast cancers. Here, we showed for the first the antitumoral effects of …