Protein phosphatase 2A (PP2A), in its activated form as a phosphatase, is a tumour
suppressor. However, when PP2A is phosphorylated at the tyrosine residue (pY307), it loses …

Pyk2 and Src phosphorylation is initiated by CCL18, which promotes breast cancer
metastasis via its functional G protein‐coupled receptor PITPNM3. However, the function of …

Ser/Thr protein phosphatase 5 (PP5) regulates several signaling-cascades that suppress
growth and/or facilitate apoptosis in response to genomic stress. The expression of PP5 is …

SPOCK1 is highly expressed in many types of cancer and has been recognized as a
promoter of cancer progression. Its regulatory mechanism in breast cancer (BC) remains …

The involvement of ErbB family members in breast cancer progression and metastasis has
been demonstrated by many studies. However, the downstream effectors that mediate their …

Breast cancer is the most prevalent cancer and a major cause of death in women worldwide.
Although early diagnosis and therapeutic intervention significantly improve patient survival …

Cancer cell epithelial-mesenchymal transition (EMT) is the crucial event for cancer
progression and plays a vital role in the metastasis of cancer cells. Activation of Polo-like …

Breast cancer (BC) is one of the most fatal diseases and poses critical health problems
worldwide. However, its mechanisms remain unclear. Consequently, there is an urgency to …

Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined by the
absence of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor …

Pancreatic cancer has a particularly poor prognosis compared to other tumors. The peculiar
hyperinsulin microenvironment of the pancreas is formed due to the endocrine secretion of …