Protein phosphatase 2A in the regulation of Wnt signaling, stem cells, and cancer

JJ Thompson, CS Williams - Genes, 2018 - mdpi.com
Protein phosphorylation is a ubiquitous cellular process that allows for the nuanced and
reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a heterotrimeric …

[HTML][HTML] 3-phosphoinositide dependent protein kinase-1 (PDK-1) promotes migration and invasion in gastric cancer cells through activating the NF-κB pathway

N Wu, C He, B Zhu, J Jiang, Y Chen, T Ma - Oncology research, 2017 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most common cancers and the second leading cause of
cancer deaths in the world. Many factors have been reported regarding the progression and …

Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications

A Bhardwaj, S Singh, SK Srivastava… - Molecular cancer …, 2011 - AACR
Earlier we identified PPP2CA, which encodes for the α-isoform of protein phosphatase 2A
(PP2A) catalytic subunit, as one of the downregulated genes in androgen-independent …

Phosphatase POPX2 exhibits dual regulatory functions in cancer metastasis

S Zhang, T Weng, E Cheruba, T Guo… - Journal of proteome …, 2017 - ACS Publications
Cancer metastasis is a complex mechanism involving multiple processes. Previously, our
integrative proteome, transcriptome, and phosphoproteome study reported that the levels of …

RETRACTED ARTICLE: Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway

J Li, Z Song, Y Wang, Y Yin, Y Liu, R Yuan, X Nan - Tumor Biology, 2016 - Springer
Abstract Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is
associated with shorter survival times for patients. However, the molecular mechanism of …

Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

G Grech, S Baldacchino, C Saliba, MP Grixti, R Gauci… - Tumor Biology, 2016 - Springer
The complexity of the phosphatase, PP2A, is being unravelled and current research is
increasingly providing information on the association of deregulated PP2A function with …

3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer

C Fyffe, M Falasca - Cancer management and research, 2013 - Taylor & Francis
It should be noted that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is a protein
encoded by the PDPK1 gene, which plays a key role in the signaling pathways activated by …

PP4R1 interacts with HMGA2 to promote non‐small‐cell lung cancer migration and metastasis via activating MAPK/ERK‐induced epithelial‐mesenchymal transition

B Wang, LY Pan, N Kang… - Molecular Carcinogenesis, 2020 - Wiley Online Library
Protein phosphatase 4 regulatory subunit 1 (PP4R1) has been shown to play a role in the
regulation of centrosome maturation, apoptosis, DNA repair, and tumor necrosis factor …

Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial‐mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 …

B Xiao, Z Kuang, W Zhang, J Hang… - Molecular …, 2019 - Wiley Online Library
Abstract Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) is an important
excitatory neurotransmitter receptor that plays a significant role in various …

Protein phosphatase 2 regulatory subunit B''Alpha silencing inhibits tumor cell proliferation in liver cancer

H Chen, J Xu, P Wang, Q Shu, L Huang, J Guo… - Cancer …, 2019 - Wiley Online Library
Aim To explore the effects of protein phosphatase 2 regulatory subunit B''Alpha (PPP2R3A)
on the proliferation and migration of liver cancer cells. Methods Expression of PPP2R3A in …