High expression of SPAG 5 sustains the malignant growth and invasion of breast cancer cells through the activation of Wnt/β‐catenin signalling
J Jiang, J Wang, X He, W Ma, L Sun… - Clinical and …, 2019 - Wiley Online Library
Summary Sperm‐associated antigen 5 (SPAG 5) has currently emerged as a novel
oncogene in various cancers. High expression of SPAG 5 has been frequently detected in …
oncogene in various cancers. High expression of SPAG 5 has been frequently detected in …
Combination of 3PO analog PFK15 and siPFKL efficiently suppresses the migration, colony formation ability, and PFK‐1 activity of triple‐negative breast cancers by …
Among all the subtypes of breast cancer, triple‐negative breast cancer (TNBC) has been
associated with the worst prognosis. Recently, for many solid tumors (including breast …
associated with the worst prognosis. Recently, for many solid tumors (including breast …
Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ
H Li, N Xiao, Y Wang, R Wang, Y Chen, W Pan, D Liu… - Oncogene, 2017 - nature.com
Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ), a phospholipid kinase generating
PIP2, is positively expressed in breast cancer tissues, which correlates intimately with the …
PIP2, is positively expressed in breast cancer tissues, which correlates intimately with the …
Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
Identifying the substrates and biochemical pathway regulated by phosphatases has always
been more challenging than finding those regulated by kinases. Here, we report the use of …
been more challenging than finding those regulated by kinases. Here, we report the use of …
[HTML][HTML] Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor …
K Hu, JH Law, A Fotovati, SE Dunn - Breast Cancer Research, 2012 - Springer
Introduction Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due
to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44 …
to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44 …
[HTML][HTML] Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling
MW Usman, J Gao, T Zheng, C Rui, T Li, X Bian… - Cell death & …, 2018 - nature.com
The PI3K pathway is one of the most dysregulated signaling pathways in epithelial cancers
and has become an attractive therapeutic target under active preclinical and clinical …
and has become an attractive therapeutic target under active preclinical and clinical …
[HTML][HTML] Breast cancer malignant processes are regulated by Pax-5 through the disruption of FAK signaling pathways
S Benzina, J Harquail, R Guerrette, P O'Brien… - Journal of …, 2016 - ncbi.nlm.nih.gov
The study of genetic factors regulating breast cancer malignancy is a top priority to mitigate
the morbidity and mortality associated with this disease. One of these factors, Pax-5 …
the morbidity and mortality associated with this disease. One of these factors, Pax-5 …
[HTML][HTML] SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stability via the PI3K/AKT/GSK3β signaling pathway
Y Yuan, Y Fan, Z Gao, X Sun, H Zhang… - Cancer biology & …, 2020 - ncbi.nlm.nih.gov
Objective: The tyrosine phosphatase SHP2 has a dual role in cancer initiation and
progression in a tissue type-dependent manner. Several studies have linked SHP2 to the …
progression in a tissue type-dependent manner. Several studies have linked SHP2 to the …
[HTML][HTML] Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB
J Xue, C Chen, M Qi, Y Huang, L Wang, Y Gao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The programmed death-ligand 1 (PD-L1), by binding to PD-1 on the surface of immune cells,
activates a major immune checkpoint pathway. Elevated expression of PD-L1 in tumor cells …
activates a major immune checkpoint pathway. Elevated expression of PD-L1 in tumor cells …
p90/CIP2A mediates breast cancer cell proliferation and apoptosis
X Liu, B Peng, Y Li, N Lei, W Li, JY Zhang - Molecular biology reports, 2014 - Springer
Cancerous inhibitor of PP2A (p90/CIP2A) was recently characterized as an innovative
oncoprotein in human malignancies. p90/CIP2A inhibited c-Myc-associated PP2A …
oncoprotein in human malignancies. p90/CIP2A inhibited c-Myc-associated PP2A …