The PI3K pathway is one of the most dysregulated signaling pathways in epithelial cancers
and has become an attractive therapeutic target under active preclinical and clinical …

Summary Sperm‐associated antigen 5 (SPAG 5) has currently emerged as a novel
oncogene in various cancers. High expression of SPAG 5 has been frequently detected in …

Introduction Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due
to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44 …

Among all the subtypes of breast cancer, triple‐negative breast cancer (TNBC) has been
associated with the worst prognosis. Recently, for many solid tumors (including breast …

PyK2 is a member of the proline-rich tyrosine kinase and focal adhesion kinase families and
is ubiquitously expressed. PyK2 is mainly activated by stimuli, such as activated Src kinases …

In this study, we aimed to investigate the antitumor effect of LYG-202, a newly synthesized
piperazine-substituted derivative of flavonoid on human breast cancer cells and illustrate the …

Type Iγ phosphatidylinositol phosphate kinase (PIPKIγ), a phospholipid kinase generating
PIP2, is positively expressed in breast cancer tissues, which correlates intimately with the …

Background The serine/threonine kinase PAK1 is an important regulator of cell motility. Both
PAK1 and the hormone/cytokine prolactin (PRL) have been implicated in breast cancer cell …

Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of pyrophosphate to form
orthophosphate. Pyrophosphate can substitute for ATP under certain circumstances. We …

Identifying the substrates and biochemical pathway regulated by phosphatases has always
been more challenging than finding those regulated by kinases. Here, we report the use of …