Human telomerase reverse transcriptase gene promoter mutation in serum of patients with hepatocellular carcinoma

S Ako, K Nouso, H Kinugasa, H Matsushita… - Oncology, 2020 - karger.com
Background: Mutations in the human telomerase reverse transcriptase (hTERT) gene
promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of …

[PDF][PDF] Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors

J Jiao, GP Watt, HL Stevenson… - Hepatology …, 2018 - Wiley Online Library
Telomerase reverse transcriptase (TERT) mutation is the most frequent genetic alteration in
hepatocellular carcinoma (HCC). Our aims were to investigate whether TERT mutations can …

[HTML][HTML] Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

D Cevik, G Yildiz, M Ozturk - World Journal of Gastroenterology …, 2015 - ncbi.nlm.nih.gov
AIM: To determine the mutation status of human telomerase reverse transcriptase gene
(TERT) promoter region in hepatocellular carcinoma (HCC) from different geographical …

Clinical significance of telomerase reverse-transcriptase promoter mutations in hepatocellular carcinoma

F Pezzuto, F Izzo, P De Luca, E Biffali, L Buonaguro… - Cancers, 2021 - mdpi.com
Simple Summary Activating mutations in the promoter region of TERT (TERTp) gene are
frequently observed in low-and high-grade dysplastic nodules and defined as early events …

Prediction of the prognosis of advanced hepatocellular carcinoma by TERT promoter mutations in circulating tumor DNA

M Hirai, H Kinugasa, K Nouso… - Journal of …, 2021 - Wiley Online Library
Background andAim Human telomerase reverse transcriptase (TERT) promoter mutations
were the most prevalent mutations in patients with hepatocellular carcinoma (HCC). We tried …

Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma

Y Takuma, K Nouso, Y Kobayashi… - Journal of …, 2004 - Wiley Online Library
Abstract Background and Aim: Telomerase activation is essential for the immortality of
cancer cells. The expression of telomerase reverse transcriptase (hTERT), the catalytic …

Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma

HW Lee, TI Park, SY Jang, SY Park, WJ Park, SJ Jung… - Medicine, 2017 - journals.lww.com
Promoter mutations in telomerase reverse transcriptase (TERT) and telomere length have
been studied in various tumors. In the present study, the frequency and clinical …

[HTML][HTML] TERT promoter mutation in resectable hepatocellular carcinomas: a strong association with hepatitis C infection and absence of hepatitis B infection

YL Chen, YM Jeng, CN Chang, HJ Lee, HC Hsu… - International Journal of …, 2014 - Elsevier
Introduction Mutation in the core promoter of the telomerase reverse transcriptase (TERT)
gene was determined to be a frequent event in malignant melanoma and other cancers …

[HTML][HTML] Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma

W Huang, W Zhou, C Li, Y Yang, YK Shang, C Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Reactivation of telomerase is a critical step in the development of hepatocellular carcinoma
(HCC). Here we identified the frequency of mutations in telomerase reverse transcriptase …

Detection of TERT promoter mutation in serum cell‐free DNA using wild‐type blocking PCR combined with Sanger sequencing in hepatocellular carcinoma

N Akuta, F Suzuki, M Kobayashi… - Journal of Medical …, 2020 - Wiley Online Library
Telomerase reverse transcriptase (TERT) promoter mutation is the most frequent genetic
alteration in hepatocellular carcinoma (HCC). However, there is currently no suitable highly …