Oxygen at the Interface of Filamentous Fungal Biofilm Morphology and Physiology
CH Kowalski - 2020 - search.proquest.com
Oxygen is the most abundant element in Earth's crust and makes up 21% of Earth's
atmosphere. Oxygen is critical element for life where it functions both as a terminal electron …
atmosphere. Oxygen is critical element for life where it functions both as a terminal electron …
Fungal biofilm morphology impacts hypoxia fitness and disease progression
CH Kowalski, JD Kerkaert, KW Liu, MC Bond… - Nature …, 2019 - nature.com
Microbial populations form intricate macroscopic colonies with diverse morphologies whose
functions remain to be fully understood. Despite fungal colonies isolated from environmental …
functions remain to be fully understood. Despite fungal colonies isolated from environmental …
A Heterogeneously Expressed Gene Family Modulates the Biofilm Architecture and Hypoxic Growth of Aspergillus fumigatus
The genus Aspergillus encompasses human pathogens such as Aspergillus fumigatus and
industrial powerhouses such as Aspergillus niger. In both cases, Aspergillus biofilms have …
industrial powerhouses such as Aspergillus niger. In both cases, Aspergillus biofilms have …
Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance
CH Kowalski, KA Morelli, D Schultz… - Proceedings of the …, 2020 - National Acad Sciences
Human fungal infections may fail to respond to contemporary antifungal therapies in vivo
despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro …
despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro …
[HTML][HTML] Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression
KA Morelli, JD Kerkaert, RA Cramer - PLoS Pathogens, 2021 - journals.plos.org
Aspergillus fumigatus is a saprophytic, filamentous fungus found in soils and compost and
the causative agent of several pulmonary diseases in humans, birds, and other mammals. A …
the causative agent of several pulmonary diseases in humans, birds, and other mammals. A …
Implications of hypoxic microenvironments during invasive aspergillosis
SJ Wezensky, RA Cramer Jr - Medical Mycology, 2011 - Taylor & Francis
In order to cause disease, all pathogens must tolerate microenvironmental stresses
encountered in vivo during infection. One microenvironmental stress that is known to occur …
encountered in vivo during infection. One microenvironmental stress that is known to occur …
[HTML][HTML] Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation
KM Shepardson, LY Ngo, V Aimanianda, JP Latge… - Microbes and …, 2013 - Elsevier
Infection by the human fungal pathogen Aspergillus fumigatus induces hypoxic
microenvironments within the lung that can alter the course of fungal pathogenesis. How …
microenvironments within the lung that can alter the course of fungal pathogenesis. How …
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?
N Grahl, RA Cramer Jr - Medical mycology, 2010 - academic.oup.com
Over the past two decades, the incidence of fungal infections has dramatically increased.
This is primarily due to increases in the population of immunocompromised individuals …
This is primarily due to increases in the population of immunocompromised individuals …
[HTML][HTML] Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Background Aspergillus fumigatus is a mold responsible for the majority of cases of
aspergillosis in humans. To survive in the human body, A. fumigatus must adapt to …
aspergillosis in humans. To survive in the human body, A. fumigatus must adapt to …
A resistant niche
A Du Toit - Nature Reviews Microbiology, 2020 - nature.com
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