Oxygen at the Interface of Filamentous Fungal Biofilm Morphology and Physiology

CH Kowalski - 2020 - search.proquest.com
Oxygen is the most abundant element in Earth's crust and makes up 21% of Earth's
atmosphere. Oxygen is critical element for life where it functions both as a terminal electron …

Fungal biofilm morphology impacts hypoxia fitness and disease progression

CH Kowalski, JD Kerkaert, KW Liu, MC Bond… - Nature …, 2019 - nature.com
Microbial populations form intricate macroscopic colonies with diverse morphologies whose
functions remain to be fully understood. Despite fungal colonies isolated from environmental …

A Heterogeneously Expressed Gene Family Modulates the Biofilm Architecture and Hypoxic Growth of Aspergillus fumigatus

CH Kowalski, KA Morelli, JE Stajich, CD Nadell… - MBio, 2021 - Am Soc Microbiol
The genus Aspergillus encompasses human pathogens such as Aspergillus fumigatus and
industrial powerhouses such as Aspergillus niger. In both cases, Aspergillus biofilms have …

Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance

CH Kowalski, KA Morelli, D Schultz… - Proceedings of the …, 2020 - National Acad Sciences
Human fungal infections may fail to respond to contemporary antifungal therapies in vivo
despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro …

[HTML][HTML] Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression

KA Morelli, JD Kerkaert, RA Cramer - PLoS Pathogens, 2021 - journals.plos.org
Aspergillus fumigatus is a saprophytic, filamentous fungus found in soils and compost and
the causative agent of several pulmonary diseases in humans, birds, and other mammals. A …

Implications of hypoxic microenvironments during invasive aspergillosis

SJ Wezensky, RA Cramer Jr - Medical Mycology, 2011 - Taylor & Francis
In order to cause disease, all pathogens must tolerate microenvironmental stresses
encountered in vivo during infection. One microenvironmental stress that is known to occur …

[HTML][HTML] Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

KM Shepardson, LY Ngo, V Aimanianda, JP Latge… - Microbes and …, 2013 - Elsevier
Infection by the human fungal pathogen Aspergillus fumigatus induces hypoxic
microenvironments within the lung that can alter the course of fungal pathogenesis. How …

Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?

N Grahl, RA Cramer Jr - Medical mycology, 2010 - academic.oup.com
Over the past two decades, the incidence of fungal infections has dramatically increased.
This is primarily due to increases in the population of immunocompromised individuals …

[HTML][HTML] Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter

BM Barker, K Kroll, M Vödisch, A Mazurie, O Kniemeyer… - BMC genomics, 2012 - Springer
Background Aspergillus fumigatus is a mold responsible for the majority of cases of
aspergillosis in humans. To survive in the human body, A. fumigatus must adapt to …

A resistant niche

A Du Toit - Nature Reviews Microbiology, 2020 - nature.com
A resistant niche | Nature Reviews Microbiology Skip to main content Thank you for visiting
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