Aberrant activation of Notch1 signaling in glomerular endothelium induces albuminuria

L Li, Q Liu, T Shang, W Song, D Xu, TD Allen… - Circulation …, 2021 - Am Heart Assoc
Rationale: Glomerular capillaries are lined with a highly specialized fenestrated
endothelium and contribute to the glomerular filtration barrier. The Notch signaling pathway …

[HTML][HTML] Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

M Murea, JK Park, S Sharma, H Kato, A Gruenwald… - Kidney international, 2010 - Elsevier
Recent studies indicate that the Notch signaling pathway plays an important role in the
development of diabetic kidney disease and focal segmental glomerulosclerosis (FSGS) …

The story of Notch and chronic kidney disease

S Sharma, Y Sirin, K Susztak - Current opinion in nephrology and …, 2011 - journals.lww.com
The story of Notch and chronic kidney disease : Current Opinion in Nephrology and
Hypertension The story of Notch and chronic kidney disease : Current Opinion in Nephrology …

[HTML][HTML] The role of Notch in the kidney, development and beyond

Y Sirin, K Susztak - The Journal of pathology, 2012 - ncbi.nlm.nih.gov
Notch is a highly conserved cell-cell communication mechanism that regulates
development, tissue homeostasis and repair. Recent studies indicate that Notch plays a key …

Blocking Notch in endothelial cells prevents arteriovenous fistula failure despite CKD

Y Wang, A Liang, J Luo, M Liang, G Han… - Journal of the …, 2014 - journals.lww.com
Neointima formation causes the failure of 60% of arteriovenous fistulas (AVFs) within 2
years. Neointima-forming mechanisms are controversial but possibly linked to excess …

Notch signaling in diabetic nephropathy

R Bonegio, K Susztak - Experimental cell research, 2012 - Elsevier
Notch signaling is an evolutionarily conserved cell–cell signaling system that controls the
fate of cells during development. In this review, we will summarize the literature that notch …

Notch in the kidney: development and disease

Y Sirin, K Susztak - The Journal of pathology, 2012 - Wiley Online Library
Notch signalling is a highly conserved cell–cell communication mechanism that regulates
development, tissue homeostasis, and repair. Within the kidney, Notch has an important …

The role of Notch3 signaling in kidney disease

C Yuan, L Ni, C Zhang, X Wu - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Notch receptors are transmembrane proteins that are members of the epidermal growth
factor‐like family. These receptors are widely expressed on the cell surface and are highly …

Notch1 signaling is limited in healthy mature kidneys in vivo

R Sugiura, T Nakayama, T Nishino, N Sambe… - BMC Research …, 2023 - Springer
Abstract Objective A Delta-Notch signaling component, Notch1, is involved in the normal
development and multiple disorders of the kidney. Although the increase in Notch1 signaling …

Modulation of Notch-1 signaling alleviates vascular endothelial growth factor–mediated diabetic nephropathy

CL Lin, FS Wang, YC Hsu, CN Chen, MJ Tseng… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Disturbances in podocytes are typically associated with marked proteinuria, a
hallmark of diabetic nephropathy. This study was conducted to investigate modulation of …