The ability to sense proteasome insufficiency and respond by directing the transcriptional
synthesis of de novo proteasomes is a trait that is conserved in evolution and is found in …

Inhibition of the proteasome leads to proteotoxic stress, which is characterized by the
buildup of ubiquitinated proteins that cannot be degraded properly. The transcription factor …

In response to proteasome dysfunction, mammalian cells upregulate proteasome gene
expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor …

Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome
subunit mRNAs are upregulated, resulting in recovery (ie,'bounce-back') of proteasome …

An important adaptation of cells to proteasome inhibition is the induction of new
proteasomes via the transcription factor Nrf1 [1, 2], which is produced as a precursor bound …

In Saccharomyces cerevisiae, chemical or genetic inhibition of proteasome activity induces
new proteasome synthesis promoted by the transcription factor RPN4. This ensures that …

In response to proteasome inhibition, the transcription factor Nrf1 facilitates de novo
synthesis of proteasomes by inducing proteasome subunit (PSM) genes [1, 2]. Previously …

Background Proteasome inhibitors are widely used in the treatment of multiple myeloma and
as research tools. Additionally, diminished proteasome function may contribute to neuronal …

Protein folding is a substantively error prone process, especially when it occurs in the
endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory …

Accumulating evidence has revealed that human cancers develop by sequentially mutating
pivotal genes, including driver genes, and acquiring cancer hallmarks. For instance, cancer …