Eukaryotic cells maintain protein homeostasis through the activity of multiple basal and
inducible systems, which function in concert to allow cells to adapt to a wide range of …

The ubiquitin–proteasome pathway plays an important role in the pathogenesis of
neurodegeneration, but mechanisms controlling expression of components in this pathway …

The transcription factor Nrf1 (NFE2L1) maintains protein homeostasis (proteostasis) by
regulating the gene expression of proteasome subunits in response to proteasome …

The transcriptional factor Nrf1 (NF-E2-related factor 1) sustains protein homeostasis
(proteostasis) by regulating the expression of proteasome genes. Under physiological …

Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger
apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of …

The 26S proteasome is a large protease complex that selectively degrades ubiquitinated
proteins. It comprises 33 distinct subunits, each of which differ in function and structure, and …

The 26S proteasome is a multisubunit complex that catalyzes the degradation of
ubiquitinated proteins. The proteasome comprises 33 distinct subunits, all of which are …

Coordinated regulation of the ubiquitin-proteasome system (UPS) is crucial for the cell to
adjust its protein degradation capacity to changing proteolytic requirements. We have shown …

Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring
proteostasis. Our previous studies have established a firm role for the transcription factor …

The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in
cells. These pathways are interdependent, and dysfunction in either pathway causes …