Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy

Y Nihei, H Suzuki, Y Suzuki - Frontiers in Immunology, 2023 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant isotype of antibodies, provides a first line of
defense at mucosal surfaces against pathogens, and thereby contributes to mucosal …

[HTML][HTML] Secondary IgA nephropathy shares the same immune features with primary IgA nephropathy

M Wang, J Lv, X Zhang, P Chen, M Zhao… - Kidney international …, 2020 - Elsevier
Introduction Galactose-deficient IgA1 (Gd-IgA1) and related IgA/IgG immune complexes
have been identified as the key drivers in the pathogenesis of IgA nephropathy (IgAN) …

Aberrantly glycosylated IgA1 in IgA nephropathy: What we know and what we don't know

Y Ohyama, MB Renfrow, J Novak… - Journal of Clinical …, 2021 - mdpi.com
IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, is
characterized by glomerular deposition of IgA1-containing immune complexes. The IgA1 …

IgA nephropathy

KN Lai, SCW Tang, FP Schena, J Novak… - Nature reviews Disease …, 2016 - nature.com
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

Insights into the role of mucosal immunity in IgA nephropathy

Y Zhang, H Zhang - Clinical Journal of the American Society of …, 2018 - journals.lww.com
IgA nephropathy is the most common form of primary GN worldwide. It is characterized by
the deposition of IgA1 (in particular, galactose-deficient IgA1) in the mesangial area of the …

[HTML][HTML] Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy

LX Xu, MH Zhao - Kidney international, 2005 - Elsevier
Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of
IgA nephropathy. Background IgA nephropathy (IgAN) is the most common …

The origin and activities of IgA1-containing immune complexes in IgA nephropathy

B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

Cellular Signaling and Production of Galactose‐Deficient IgA1 in IgA Nephropathy, an Autoimmune Disease

C Reily, H Ueda, ZQ Huang, J Mestecky… - Journal of …, 2014 - Wiley Online Library
Immunoglobulin A (IgA) nephropathy (IgAN), the leading cause of primary
glomerulonephritis, is characterized by IgA1‐containing immunodeposits in the glomeruli …

Pathogenesis of IgA nephropathy: current understanding and implications for development of disease-specific treatment

B Knoppova, C Reily, RG King, BA Julian… - Journal of Clinical …, 2021 - mdpi.com
IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …

Aberrantly glycosylated IgA1 as a factor in the pathogenesis of IgA nephropathy

M Tanaka, G Seki, T Someya… - Journal of Immunology …, 2011 - Wiley Online Library
Predominant or codominant immunoglobulin (Ig) A deposition in the glomerular mesangium
characterizes IgA nephropathy (IgAN). Accumulated glomerular IgA is limited to the IgA1 …