Interstitial cystitis/bladder pain syndrome (IC/BPS) is a type of chronic bladder inflammation
characterized by increased voiding frequency, urgency and pelvic pain. The sensitization of …

Urinary bladder pain is a primary symptom associated with interstitial cystitis/painful bladder
syndrome. We used systemic injections of cyclophosphamide (CYP), an alkylating …

Using patch-clamp techniques, we studied the plasticity of acid-sensing ion channels (ASIC)
and transient receptor potential V1 (TRPV1) channel function in dorsal root ganglia (DRG) …

Cyclophosphamide (CYP) induces an interstitial cystitis-like inflammation. The resulting
bladder dysfunction has been associated with increased release of adenosine-5 …

Bladder disorders associated with interstitial cystitis are frequently characterized by
increased contractility and pain. The goals of this study were to examine 1) the effects of …

Interstitial cystitis (IC) is a syndrome of bladder hypersensitivity with symptoms of urgency,
frequency, and chronic pelvic pain. Although no consensus has been reached on the …

Painful bladder syndrome/Interstitial cystitis (PBS/IC) is a chronic disorder characterized
clinically by recurring episodes of pelvic pain and increased urination frequency …

Background The activation of TRPA1 channel is implicated in hyper-reflexic micturition
similar to overactive bladder. In this study, we aimed to investigate the effects of blocking …

Aims Adenosine is a neurotransmitter that exerts numerous physiological effects in many
organs. However, few studies have focused on the role of adenosine receptors in the control …

Aims To evaluate sympathetic system activity in bladder pain syndrome/interstitial cystitis
(BPS/IC) patients and to investigate if chronic adrenergic stimulation in intact rats induces …