TRPV1 and mast cell involvement in repeated variate stress-induced urinary bladder dysfunction in adult female mice
AB Sidwell, BM Girard, SE Campbell… - American Journal of …, 2024 - journals.physiology.org
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) is unknown but likely
multifactorial. IC/BPS symptoms can be exacerbated by psychological stress, but underlying …
multifactorial. IC/BPS symptoms can be exacerbated by psychological stress, but underlying …
GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models
A Charrua, CD Cruz, S Narayanan, L Gharat… - The Journal of …, 2009 - Elsevier
PURPOSE: We evaluated the effects of GRC-6211, an orally active TRPV1 antagonist, on
the function and noxious input of naïve and inflamed bladders. MATERIALS AND …
the function and noxious input of naïve and inflamed bladders. MATERIALS AND …
Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats
N Hayashi, N Kawamorita, Y Ishizuka, S Kimura… - International …, 2023 - Springer
Introduction and hypothesis In women with chronic pelvic pain (CPP), interstitial
cystitis/bladder pain syndrome (IC/BPS) and endometriosis frequently coexist. The …
cystitis/bladder pain syndrome (IC/BPS) and endometriosis frequently coexist. The …
Pharmacological validation of a model of cystitis pain in the mouse
C Wantuch, M Piesla, L Leventhal - Neuroscience letters, 2007 - Elsevier
Interstitial cystitis (IC) is a chronic pelvic-perineal pain syndrome of unknown etiology that
mainly targets the lower urinary tract. Pain is the most prominent feature of IC and current …
mainly targets the lower urinary tract. Pain is the most prominent feature of IC and current …
Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis
M Zhao, L Liu, Z Chen, N Ding, J Wen, J Liu, N Ge… - Pain, 2022 - journals.lww.com
The transient receptor potential cation channel subfamily M member-3 (TRPM3) channel is a
recently recognized noxious heat sensor that is involved in inflammatory thermal …
recently recognized noxious heat sensor that is involved in inflammatory thermal …
Oxybutynin and propiverine suppress adenosine triphosphate-induced bladder overactivity other than through antimuscarinic mechanisms
HS Moon, JW Lee, SY Park, YW Son, YT Kim - Urology, 2010 - Elsevier
OBJECTIVES: Adenosine triphosphate (ATP) is released from bladder urothelium in
response to stretch and may act as a sensory neurotransmitter. ATP release from the …
response to stretch and may act as a sensory neurotransmitter. ATP release from the …
Acute intravesical capsaicin for the study of TRPV1 in the lower urinary tract: clinical relevance and potential for innovation
Capsaicin acts on sensory nerves via vanilloid receptors. TRPV1 has been extensively
studied with respect to functional lower urinary tract (LUT) conditions in rodents and …
studied with respect to functional lower urinary tract (LUT) conditions in rodents and …
[HTML][HTML] Artemin immunotherapy is effective in preventing and reversing cystitis-induced bladder hyperalgesia via TRPA1 regulation
Injury-or disease-induced artemin (ARTN) signaling can sensitize primary afferents and
contribute to persistent pain. We demonstrate that administration of an ARTN neutralizing …
contribute to persistent pain. We demonstrate that administration of an ARTN neutralizing …
Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: a MAPP Research Network animal study
X Cui, X Jing, SK Lutgendorf… - American Journal …, 2019 - journals.physiology.org
Altered Toll-like receptor (TLR) 4 activation has been identified in several chronic pain
conditions but has not been well studied in interstitial cystitis/bladder pain syndrome …
conditions but has not been well studied in interstitial cystitis/bladder pain syndrome …
Herpes simplex virus vector-mediated gene delivery of poreless TRPV1 channels reduces bladder overactivity and nociception in rats
T Majima, Y Funahashi, S Takai, WF Goins… - Human gene …, 2015 - liebertpub.com
Increased afferent excitability has been proposed as an important pathophysiology of
interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB). In this …
interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB). In this …