A common dilemma faced by all animal bioethics committees arises when exceptions are
proposed to the use of analgesics in painful procedures. The committee and researcher …

There exists currently a fair degree of introspection in the pain research community about
the value of animal research. This review represents a defense of animal research in pain …

The use of animals in research adheres to scientific and ethical principles that promote
humane care and practice. Scientific advances in our understanding of animal physiology …

The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

The current gap between basic science research and the development of new analgesics
presents a serious challenge for the future of pain medicine. This challenge is particularly …

The paradoxical goal of much of animal-based biomedical research is to model severe
human injuries and illnesses without causing severe pain or distress to the animals. Current …

Failure of analgesic drugs in clinical development is common. Along with the current
“reproducibility crisis” in pain research, this has led some to question the use of animal …

One of the biggest challenges for analgesic drug development is how to decide if a potential
analgesic candidate will work in humans. What preclinical data are the most convincing …

The study of pain and analgesia is an important area of biomedical research which has led
to a number of significant advances in the treatment of acute and chronic pain in the clinic …

A potential cause of suffering in animal experimentation is pain induced by procedures,
diseases, and injuries. Pain is not only nociception, the sensory nervous system's response …