Therapeutic approach to Alzheimer's disease: Current treatments and new perspectives

T Pardo-Moreno, A González-Acedo… - Pharmaceutics, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. The pathophysiology of
this disease is characterized by the accumulation of amyloid-β, leading to the formation of …

Two decades of new drug discovery and development for Alzheimer's disease

Z Liu, A Zhang, H Sun, Y Han, L Kong, X Wang - RSC advances, 2017 - pubs.rsc.org
Alzheimer's disease is a progressive and irreversible neurodegenerative disease,
associated with a decreased cognitive function and severe behavioral abnormalities. Due to …

Novel insights for the treatment of Alzheimer's disease

A Kurz, R Perneczky - Progress in Neuro-Psychopharmacology and …, 2011 - Elsevier
The development of treatments for Alzheimer's disease (AD) is currently shifting away from
the correction of neurotransmitter abnormalities and from attempts to remove the …

Current drug targets for Alzheimer's disease treatment

DK Lahiri, MR Farlow, NH Greig… - Drug development …, 2002 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia among the elderly, is
a progressive, degenerative disorder of the brain with a loss of memory and cognition. A …

Current and future therapy in Alzheimer's disease

RJ Van Marum - Fundamental & clinical pharmacology, 2008 - Wiley Online Library
Dementia is increasingly being recognized as one of the most important medical problems
in the elderly. As most pharmacological research within the field of dementia is focused on …

Therapeutic approaches to Alzheimer's disease

HW Klafki, M Staufenbiel, J Kornhuber, J Wiltfang - Brain, 2006 - academic.oup.com
Alzheimer's disease is an age-related progressive neurodegenerative disorder with an
enormous unmet medical need. It is the most common form of dementia affecting∼ 5% of …

[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical Pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

Review of drugs for Alzheimer's disease

X Sun, L Jin, P Ling - Drug discoveries & therapeutics, 2012 - jstage.jst.go.jp
Alzheimer's disease (AD) is the most common form of dementia in the elderly. The number of
people affected by AD is rapidly increasing. AD is characterized by cerebral atrophy …

Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development

NR Cutler, JJ Sramek - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
AD is believed to stem from dysfunctional cholinergic signaling in the regions of the brain
associated with memory and cognition. 2. The occurrence of AD in afflicted individuals …

Alzheimer's disease hypothesis and related therapies

X Du, X Wang, M Geng - Translational neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause for dementia. There are many hypotheses about AD, including abnormal …