Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application …
EN Ter Horst, PAJ Krijnen, N Hakimzadeh… - Basic Research in …, 2019 - Springer
Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial
infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in …
infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in …
A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction
S Finger, M Knorr, M Molitor, R Schüler… - Cardiovascular …, 2019 - academic.oup.com
Aims Myelomonocytic cells are critical in injury and healing post-myocardial infarction (MI).
Mechanisms of regulation, however, are incompletely understood. The aim of the study was …
Mechanisms of regulation, however, are incompletely understood. The aim of the study was …
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved …
Aims Monocytes play critical roles in tissue injury and repair following acute myocardial
infarction (AMI). Specifically targeting inflammatory monocytes in experimental models leads …
infarction (AMI). Specifically targeting inflammatory monocytes in experimental models leads …
Interferon-γ regulates cardiac myeloid cells in myocardial infarction
FF Hoyer, M Nahrendorf - Cardiovascular research, 2019 - academic.oup.com
Interferons' interferences with viral replication were discovered more than 60 years ago. 1
Today, we know that interferons (IFNs) are involved in a multitude of processes in innate and …
Today, we know that interferons (IFNs) are involved in a multitude of processes in innate and …
The systemic deletion of interleukin-1α reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction
Myocardial inflammation following myocardial infarction (MI) is crucial for proper myocardial
healing, yet, dysregulated inflammation may promote adverse ventricular remodeling and …
healing, yet, dysregulated inflammation may promote adverse ventricular remodeling and …
Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling
J Song, RA Frieler, SE Whitesall… - American Journal …, 2021 - journals.physiology.org
Interleukin-4 receptor α (IL4Rα) signaling plays an important role in cardiac remodeling
during myocardial infarction (MI). However, the target cell type (s) of IL4Rα signaling during …
during myocardial infarction (MI). However, the target cell type (s) of IL4Rα signaling during …
[HTML][HTML] Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following …
MJ Daseke II, MAA Tenkorang-Impraim, Y Ma… - Journal of molecular and …, 2020 - Elsevier
Introduction Macrophages and neutrophils are primary leukocytes involved in the
inflammatory response to myocardial infarction (MI). While interleukin (IL)-4 is an in vitro anti …
inflammatory response to myocardial infarction (MI). While interleukin (IL)-4 is an in vitro anti …
Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis
Y Han, Y Li, L Jia, J Cheng, Y Qi, H Zhang, J Du - PloS one, 2012 - journals.plos.org
Background The inflammatory response plays a critical role in hypertension-induced cardiac
remodeling. We aimed to study how interaction among inflammatory cells causes …
remodeling. We aimed to study how interaction among inflammatory cells causes …
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling
M Bujak, M Dobaczewski, K Chatila… - The American journal of …, 2008 - Elsevier
The proinflammatory cytokine interleukin (IL)-1 signals exclusively through the type I IL-1
receptor (IL-1RI). IL-1 expression is markedly induced in the infarcted heart; however, its role …
receptor (IL-1RI). IL-1 expression is markedly induced in the infarcted heart; however, its role …
IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation
M Jung, Y Ma, RP Iyer, KY DeLeon-Pennell… - Basic research in …, 2017 - Springer
Inflammation resolution is important for scar formation following myocardial infarction (MI)
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …
and requires the coordinated actions of macrophages and fibroblasts. In this study, we …