The center of it all: An antitumor‐active trinuclear platinum complex forms unprecedented
interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow …

The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear
bisplatinum complexes. To understand the molecular mechanisms underlying the biological …

The DNA binding ability and binding mode of platinum complexes are crucial factors that
govern their cytotoxic activity. In this work, circular dichroism spectroscopy, gel …

Polynuclear platinum compounds comprise a unique class of anticancer agents with
chemical and biological properties different from mononuclear platinum drugs. The lead …

The trinuclear platinum compound [{trans‐PtCl (NH3) 2} 2 (μ‐trans‐Pt (NH3) 2 {NH2 (CH2)
6NH2} 2)] 4+(BBR3464) belongs to the polynuclear class of platinum‐based anticancer …

This Comment summarises the chemistry and DNA binding of dinuclear platinum-amine, or
bis (platinum), complexes, a new class of potent antitumor agents. In these structures, the Pt …

The novel anticancer drug ([{trans-PtCl (NH3) 2} 2-μ-{trans-Pt (NH3) 2 (NH2 (CH2) 6NH2)
2}](NO3) 4)(BBR3464, 1, 0, 1/t, t, t, TPC) forms a 1, 4-interstrand cross-linked adduct with the …

Polynuclear platinum complexes (PPCs) represent a discrete structural class of DNA-
binding agents with excellent antitumor properties. The use of at least two platinum …

Reported herein is a study of the unusual 3′–3′ 1, 4‐GG interstrand cross‐link (IXL)
formation in duplex DNA by a series of polynuclear platinum anticancer complexes. To …

When antitumor platinum drugs react with DNA they form various types of intrastrand and
interstrand cross-links (CLs). One class of new antitumor platinum compounds comprises …