Walking of antitumor bifunctional trinuclear Pt II complex on double-helical DNA
J Malina, J Kasparkova, NP Farrell… - Nucleic acids …, 2011 - academic.oup.com
Abstract The trinuclear BBR3464 ([{trans-PtCl (NH 3) 2} 2 µ-(trans-Pt (NH 3) 2 (H 2 N (CH 2)
6 NH 2) 2)] 4+) belongs to the polynuclear class of platinum-based anticancer agents. DNA …
6 NH 2) 2)] 4+) belongs to the polynuclear class of platinum-based anticancer agents. DNA …
A Pyrazolato‐Bridged Dinuclear Platinum(II) Complex Induces Only Minor Distortions upon DNA‐Binding
S Teletchéa, S Komeda, JM Teuben… - … A European Journal, 2006 - Wiley Online Library
The cytotoxic, pyrazolato‐bridged dinuclear platinum (ii) complex [(cis‐{Pt (NH3) 2}) 2 (μ‐
OH)(μ‐pz)] 2+(pz= pyrazolate) has been found to cross‐link two adjacent guanines of a …
OH)(μ‐pz)] 2+(pz= pyrazolate) has been found to cross‐link two adjacent guanines of a …
Antitumor bifunctional dinuclear PtII complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions
T Muchova, SM Quintal, NP Farrell, V Brabec… - JBIC Journal of …, 2012 - Springer
When antitumor platinum drugs react with DNA they form various types of intrastrand and
interstrand cross-links (CLs). One class of new antitumor platinum compounds comprises …
interstrand cross-links (CLs). One class of new antitumor platinum compounds comprises …
Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases …
Y Qu, NJ Scarsdale, MC Tran, NP Farrell - JBIC Journal of Biological …, 2003 - Springer
The novel phase II anticancer drug BBR3464 ([{trans-PtCl (NH 3) 2} 2-µ-{trans-Pt (NH 3) 2
(NH 2 (CH 2) 6 NH 2) 2}](NO 3) 4) forms a 1, 4-interstrand cross-link adduct with the self …
(NH 2 (CH 2) 6 NH 2) 2}](NO 3) 4) forms a 1, 4-interstrand cross-link adduct with the self …
Unique DNA binding mode of antitumor trinuclear tridentate platinum (II) compound
R Olivova, J Kasparkova, O Vrana… - Molecular …, 2011 - ACS Publications
The new trinuclear tridentate PtII complex [Pt3Cl3 (hptab)] 3+(1; hptab= N, N, N′, N′,
N′′, N′′-hexakis (2-pyridylmethyl)-1, 3, 5-tris (aminomethyl) benzene) exhibits …
N′′, N′′-hexakis (2-pyridylmethyl)-1, 3, 5-tris (aminomethyl) benzene) exhibits …
Chemistry and biology of multifunctional DNA binding agents
N Farrell, Y Qu, JD Roberts - Metallopharmaceuticals I: DNA Interactions, 1999 - Springer
Dinuclear and trinuclear platinum complexes represent a new class of anticancer agents,
distinct in DNA binding and antitumor activity from their mononuclear counterparts. The first …
distinct in DNA binding and antitumor activity from their mononuclear counterparts. The first …
Synthesis, cytotoxicity, cell uptake and DNA interstrand cross‐linking of 4, 4′‐dipyrazolylmethane‐linked multinuclear platinum anti‐cancer complexes
NJ Wheate, C Cullinane, LK Webster - Anti-cancer drug design, 2001 - ingentaconnect.com
Two cationic multinuclear platinum complexes linked with the 4, 4′‐dipyrazolylmethane
(dpzm) ligand, trans‐[{Pt (NH3) 2Cl} 2‐µ‐dpzm] Cl2 (di‐Pt) and trans‐[trans‐{Pt (NH3) 2Cl} 2 …
(dpzm) ligand, trans‐[{Pt (NH3) 2Cl} 2‐µ‐dpzm] Cl2 (di‐Pt) and trans‐[trans‐{Pt (NH3) 2Cl} 2 …
A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity
Y Zhao, W He, P Shi, J Zhu, L Qiu, L Lin, Z Guo - Dalton Transactions, 2006 - pubs.rsc.org
A trinuclear 3N-chelated monofunctional platinum complex,[Pt3 (HPTAB) Cl3](ClO4) 3
(HPTAB= N, N, N′, N′, N ″, N ″-hexakis (2-pyridylmethyl)-1, 3, 5-tris (aminomethyl) …
(HPTAB= N, N, N′, N′, N ″, N ″-hexakis (2-pyridylmethyl)-1, 3, 5-tris (aminomethyl) …
Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers
L Zerzankova, H Kostrhunova, M Vojtiskova… - Biochemical …, 2010 - Elsevier
The primary objective was to understand more deeply the molecular mechanism underlying
different antitumor effects of dinuclear PtII complexes containing aromatic linkers of different …
different antitumor effects of dinuclear PtII complexes containing aromatic linkers of different …
DNA interactions of new cytotoxic tetrafunctional dinuclear platinum complex trans, trans-[{PtCl2 (NH3)} 2 (piperazine)]
V Brabec, P Christofis, M Slámová… - Biochemical …, 2007 - Elsevier
A new tetrafunctional dinuclear platinum complex trans, trans-[{PtCl2 (NH3)} 2 (piperazine)]
with sterically rigid linking group was designed, synthesized and characterized. In this novel …
with sterically rigid linking group was designed, synthesized and characterized. In this novel …