Biological consequences of trinuclear platinum complexes: comparison of [{trans-PtCl (NH3) 2} 2μ-(trans-Pt (NH3) 2 (H2N (CH2) 6-NH2) 2)] 4+(BBR 3464) with its …
[{trans-PtCl (NH3) 2} 2μ-(trans-Pt (NH3) 2 (H2N (CH2) 6NH2) 2)] 4+(BBR 3464) is a 4+
cationic trinuclear platinum drug that has undergone phase II clinical trials in the treatment of …
cationic trinuclear platinum drug that has undergone phase II clinical trials in the treatment of …
Synthesis, cytotoxic activity and DNA interaction studies of new dinuclear platinum (ii) complexes with an aromatic 1, 5-naphthyridine bridging ligand: DNA binding …
B Konovalov, MD Živković, JZ Milovanović… - Dalton …, 2018 - pubs.rsc.org
The synthesis, spectroscopic characterization, cytotoxic activity and DNA binding evaluation
of seven new dinuclear platinum (II) complexes Pt1–Pt7, with the general formula [{Pt (L) Cl} …
of seven new dinuclear platinum (II) complexes Pt1–Pt7, with the general formula [{Pt (L) Cl} …
Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp
Y Qu, RG Kipping, NP Farrell - Dalton Transactions, 2015 - pubs.rsc.org
The phosphate clamp is a distinct mode of ligand–DNA binding where the molecular
recognition is manifested through (“non-covalent”) hydrogen-bonding from am (m) ines of …
recognition is manifested through (“non-covalent”) hydrogen-bonding from am (m) ines of …
Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
ME Oehlsen, A Hegmans, Y Qu, N Farrell - JBIC Journal of Biological …, 2005 - Springer
In this study, the reactions of N-acetyl-L-methionine (AcMet) with [{trans-PtCl (NH 3) 2} 2-μ-H
2 N (CH 2) 6 NH 2](NO 3) 2 (BBR3005: 1, 1/t, t 1) and its cis analog [{cis-PtCl (NH 3) 2} 2-μ …
2 N (CH 2) 6 NH 2](NO 3) 2 (BBR3005: 1, 1/t, t 1) and its cis analog [{cis-PtCl (NH 3) 2} 2-μ …
Interaction of novel bis (platinum) complexes with DNA
JD Roberts, B Van Houten, Y Qu… - Nucleic acids …, 1989 - academic.oup.com
Abstract Bis (platinum) complexes [{cis-PtCl2 (NH3)} 2H2N (CH2) nNH2] are a novel series
of potential anticancer agents in which two cis-diamine (platinum) groups are linked by an …
of potential anticancer agents in which two cis-diamine (platinum) groups are linked by an …
Kinetic study of azole-bridged dinuclear platinum (II) complexes reacting with a hairpin-stabilized double-stranded oligonucleotide
S Komeda, S Bombard, S Perrier, J Reedijk… - Journal of inorganic …, 2003 - Elsevier
The cytotoxic dinuclear platinum (II) complexes [{cis-Pt (NH3) 2} 2 (μ-OH)(μ-pz)](NO3) 2 (pz=
pyrazolate)(1) and [{cis-Pt (NH3) 2} 2 (μ-OH)(μ-1, 2, 3-ta-N1, N2)](NO3) 2 (1, 2, 3-ta= 1, 2, 3 …
pyrazolate)(1) and [{cis-Pt (NH3) 2} 2 (μ-OH)(μ-1, 2, 3-ta-N1, N2)](NO3) 2 (1, 2, 3-ta= 1, 2, 3 …
Competitive formation of both long-range 5′–5′ and short-range antiparallel 3′–3′ DNA interstrand cross-links by a trinuclear platinum complex on binding to a …
RA Ruhayel, SJ Berners-Price, NP Farrell - Dalton Transactions, 2013 - pubs.rsc.org
2D [1H, 15N] HSQC NMR spectroscopy has been used to monitor the reaction of fully 15N-
labelled [{trans-PtCl (NH3) 2} 2 (μ-trans-Pt (NH3) 2 {NH2 (CH2) 6NH2} 2)] 4+(Triplatin …
labelled [{trans-PtCl (NH3) 2} 2 (μ-trans-Pt (NH3) 2 {NH2 (CH2) 6NH2} 2)] 4+(Triplatin …
Polynuclear platinum drugs
N Farrell - Metal ions in biological systems, 2004 - api.taylorfrancis.com
Polynuclear platinum complexes represent a discrete class of antitumor agents, distinct in
structure and biological effects from the classical mononuclear family represented by …
structure and biological effects from the classical mononuclear family represented by …
Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides
KJ Mellish, Y Qu, N Scarsdale… - Nucleic acids research, 1997 - academic.oup.com
The dinuclear platinum complexes [{trans-PtCl (NH3) 2} 2µ-{HNH2 (CH2) n NH2}](NO3) 2 [1,
1/t, t (n= 4, 6)] and [{cis-PtCl (NH3) 2} 2µ-{NH2 (CH2) n NH2}](NO3) 2 [1, 1/c, c (n= 4, 6)] …
1/t, t (n= 4, 6)] and [{cis-PtCl (NH3) 2} 2µ-{NH2 (CH2) n NH2}](NO3) 2 [1, 1/c, c (n= 4, 6)] …
A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA
A New Platinum Anticancer Drug Forms a Highly Stereoselective Adduct with Duplex DNA Page
1 COMMUNICATIONS 2060 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 1999 …
1 COMMUNICATIONS 2060 WILEY-VCH Verlag GmbH, D-69451 Weinheim, 1999 …