Small Molecules as Anti‐inflammatory Agents: Molecular Mechanisms and Heterocycles as Inhibitors of Signaling Pathways

NJ Basha - ChemistrySelect, 2023 - Wiley Online Library
Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

Heterocycles in managing inflammatory diseases

B Nehra, PA Chawla, P Prasher, DS Bhagat - Recent Developments in Anti …, 2023 - Elsevier
Inflammation remains one of the initial symptoms of the majority of various well-recognized
diseases and considered by indications such as redness, pain, swelling, and heat. Due to …

NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future

S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

[PDF][PDF] Plant based anti-inflammatory secondary metabolites

P Pushpangadan, TP Ijinu, V George - Annals of Phytomedicine, 2015 - researchgate.net
Inflammation is the body's natural response to harmful stimuli arising in tissue in response to
traumatic, infectious, post-ischemic, toxic or autoimmune injury. The resolution inflammation …

Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives

NA Gouda, SO Alshammari, MAS Abourehab… - …, 2023 - Springer
Chronic inflammation is a common underlying factor in many major diseases, including
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …

The potentials of selected therapeutic targets for inflammation: a snapshot

S Nayadu, G Kaur, G Gudi… - Recent Patents on …, 2012 - ingentaconnect.com
Inflammation is a complex integrated host response to infection and injury. Inflammatory
cells respond to foreign substances and inflammatory stimulus by producing various …

Looking at NSAIDs from a historical perspective and their current status in drug repurposing for cancer treatment and prevention

A Ozleyen, YB Yilmaz, S Donmez, HN Atalay… - Journal of Cancer …, 2023 - Springer
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed
drug classes with wide therapeutic applications over the centuries. Starting from the use of …

[HTML][HTML] Raging the war against inflammation with natural products

A Attiq, J Jalil, K Husain, W Ahmad - Frontiers in pharmacology, 2018 - frontiersin.org
Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of
choice for treating numerous inflammatory diseases including rheumatoid arthritis. The …

Management of inflammation by natural polyphenols: A comprehensive mechanistic update

S Sarkar, S Mazumder, SJ Saha… - Current medicinal …, 2016 - ingentaconnect.com
Inflammation generates a systemic response against injury or infection from bacteria,
viruses, and other pathogens. The welfare of host is the primary target of this process …

Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects

V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
Simple Summary The application of non-steroidal anti-inflammatory drugs (NSAIDs) in
cancer therapy has been a widely studied topic for almost four decades. This review …