Breast cancer stem cell (BCSC) properties are correlated with the malignancy of tumor cells.
Sulforaphane (SFN), a natural isothiocyanate, has anti-cancer effects. However, SFN is an …

Background: Tumor metastasis is a main cause of death in patients with breast cancer. The
cross-talk between cancer-associated fibroblasts (CAFs) and tumor cells plays an important …

Gastric cancer stem cells (CSCs) play a crucial role in the initiation, development, relapse
and metastasis of gastric cancer because they are resistant to a standard chemotherapy and …

In this work, we developed a novel core/shell chitosan (Cs)/hyaluronan (HA)-based hybrid
nanoparticle, ie SNX@ Cs-SNX/cHA, with good stability in the bloodstream and intracellular …

Conventional chemotherapy drugs such as paclitaxel (PTX) can effectively inhibit tumor
growth by killing the majority of the proliferating cancer cells; however, it also results in multi …

Background The long-term sequelae and serious side effects of conventional breast cancer
chemotherapy due to ubiquitous biodistribution and systemic toxicity remain the main …

The stability of self-assembled drug nanocarriers during blood circulation and the controlled
intracellular drug delivery are two challenges in cancer therapy. In this paper, we …

Metastasis and chemotherapy resistance are the leading causes of breast cancer mortality.
Celecoxib (CXB), a selective cyclooxygenase-2 (COX-2) inhibitor, has antiangiogenetic …

Background Drug nanocarriers can markedly reduce the toxicities and side effects of
encapsulated chemotherapeutic drugs in the clinic. However, these drug nanocarriers have …

Introduction Metastasis is a major challenge in breast cancer therapy. The successful
chemotherapy of breast cancer largely depends on the ability to block the metastatic …