Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons
In many tissues, including brain, prolactin action is predominantly mediated by the Janus
kinase/signal transducer and activator of transcription (STAT) signal transduction pathway …
kinase/signal transducer and activator of transcription (STAT) signal transduction pathway …
Distribution of prolactin‐responsive neurons in the mouse forebrain
RSE Brown, IC Kokay, AE Herbison… - Journal of …, 2010 - Wiley Online Library
Prolactin has numerous biological actions in the brain, and transgenic mice are increasingly
being used to investigate these actions. The present study aimed to provide a detailed …
being used to investigate these actions. The present study aimed to provide a detailed …
Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action
TJ Sapsford, IC Kokay, L Östberg… - Journal of …, 2012 - Wiley Online Library
Prolactin stimulates dopamine release from neuroendocrine dopaminergic (NEDA) neurons
in the hypothalamic arcuate nucleus (ARC) to maintain low levels of serum prolactin …
in the hypothalamic arcuate nucleus (ARC) to maintain low levels of serum prolactin …
Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse
T Georgescu, SR Ladyman, RSE Brown… - Journal of …, 2020 - Wiley Online Library
In addition to its critical role in lactation, the anterior pituitary hormone prolactin also
influences a broad range of other physiological processes. In particular, widespread …
influences a broad range of other physiological processes. In particular, widespread …
Prolactin-sensitive neurons express estrogen receptor-α and depend on sex hormones for normal responsiveness to prolactin
IC Furigo, KW Kim, VS Nagaishi, AM Ramos-Lobo… - Brain research, 2014 - Elsevier
Estrogens and prolactin share important target tissues, including the gonads, brain, liver,
kidneys and some types of cancer cells. Herein, we sought anatomical and functional …
kidneys and some types of cancer cells. Herein, we sought anatomical and functional …
Prolactin receptor‐mediated activation of pSTAT5 in the pregnant mouse brain
P Gustafson, SR Ladyman, S McFadden… - Journal of …, 2020 - Wiley Online Library
Pregnancy represents a period of remarkable adaptive physiology throughout the body, with
many of these important adaptations mediated by changes in gene transcription in the brain …
many of these important adaptations mediated by changes in gene transcription in the brain …
Effects of prolactin on hypothalamic supraoptic neurones: evidence for modulation of STAT5 expression and electrical activity.
J Townsend, BJ Cave, MR Norman, A Flynn… - Neuro endocrinology …, 2005 - europepmc.org
Objectives The study investigated the role of prolactin (PRL) in modulating STAT5 and
electrical activity of magnocellular neurones in the supraoptic (SO) nucleus of male rats …
electrical activity of magnocellular neurones in the supraoptic (SO) nucleus of male rats …
Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration
A Lerant, B Kanyicska, ME Freeman - Brain research, 2001 - Elsevier
Ample evidence indicates feedback relationships between pituitary prolactin and
hypothalamic dopaminergic neurons. Since the presence of prolactin receptors was earlier …
hypothalamic dopaminergic neurons. Since the presence of prolactin receptors was earlier …
Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons
FY Ma, GM Anderson, TD Gunn, V Goffin… - …, 2005 - academic.oup.com
The hypothalamic neuroendocrine dopaminergic (NEDA) neurons are crucial in regulating
prolactin secretion from the anterior pituitary. Rising prolactin concentrations stimulate these …
prolactin secretion from the anterior pituitary. Rising prolactin concentrations stimulate these …
Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus
Tuberoinfundibular dopamine (TIDA) neurons, known as neuroendocrine regulators of
prolactin secretion from the pituitary gland, also release GABA within the hypothalamic …
prolactin secretion from the pituitary gland, also release GABA within the hypothalamic …