Differential actions of prolactin on electrical activity and intracellular signal transduction in hypothalamic neurons

RSE Brown, R Piet, AE Herbison, DR Grattan - Endocrinology, 2012 - academic.oup.com
In many tissues, including brain, prolactin action is predominantly mediated by the Janus
kinase/signal transducer and activator of transcription (STAT) signal transduction pathway …

Distribution of prolactin‐responsive neurons in the mouse forebrain

RSE Brown, IC Kokay, AE Herbison… - Journal of …, 2010 - Wiley Online Library
Prolactin has numerous biological actions in the brain, and transgenic mice are increasingly
being used to investigate these actions. The present study aimed to provide a detailed …

Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action

TJ Sapsford, IC Kokay, L Östberg… - Journal of …, 2012 - Wiley Online Library
Prolactin stimulates dopamine release from neuroendocrine dopaminergic (NEDA) neurons
in the hypothalamic arcuate nucleus (ARC) to maintain low levels of serum prolactin …

Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse

T Georgescu, SR Ladyman, RSE Brown… - Journal of …, 2020 - Wiley Online Library
In addition to its critical role in lactation, the anterior pituitary hormone prolactin also
influences a broad range of other physiological processes. In particular, widespread …

Prolactin-sensitive neurons express estrogen receptor-α and depend on sex hormones for normal responsiveness to prolactin

IC Furigo, KW Kim, VS Nagaishi, AM Ramos-Lobo… - Brain research, 2014 - Elsevier
Estrogens and prolactin share important target tissues, including the gonads, brain, liver,
kidneys and some types of cancer cells. Herein, we sought anatomical and functional …

Prolactin receptor‐mediated activation of pSTAT5 in the pregnant mouse brain

P Gustafson, SR Ladyman, S McFadden… - Journal of …, 2020 - Wiley Online Library
Pregnancy represents a period of remarkable adaptive physiology throughout the body, with
many of these important adaptations mediated by changes in gene transcription in the brain …

Effects of prolactin on hypothalamic supraoptic neurones: evidence for modulation of STAT5 expression and electrical activity.

J Townsend, BJ Cave, MR Norman, A Flynn… - Neuro endocrinology …, 2005 - europepmc.org
Objectives The study investigated the role of prolactin (PRL) in modulating STAT5 and
electrical activity of magnocellular neurones in the supraoptic (SO) nucleus of male rats …

Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration

A Lerant, B Kanyicska, ME Freeman - Brain research, 2001 - Elsevier
Ample evidence indicates feedback relationships between pituitary prolactin and
hypothalamic dopaminergic neurons. Since the presence of prolactin receptors was earlier …

Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons

FY Ma, GM Anderson, TD Gunn, V Goffin… - …, 2005 - academic.oup.com
The hypothalamic neuroendocrine dopaminergic (NEDA) neurons are crucial in regulating
prolactin secretion from the anterior pituitary. Rising prolactin concentrations stimulate these …

Conditional deletion of the prolactin receptor reveals functional subpopulations of dopamine neurons in the arcuate nucleus of the hypothalamus

RSE Brown, IC Kokay, HR Phillipps, SH Yip… - Journal of …, 2016 - Soc Neuroscience
Tuberoinfundibular dopamine (TIDA) neurons, known as neuroendocrine regulators of
prolactin secretion from the pituitary gland, also release GABA within the hypothalamic …