Multiple sclerosis (MS) is the leading cause of chronic neurological disability in young
adults. The clinical disease course of MS varies greatly between individuals, with some …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …

γδ T cells may be important innate immune system contributors to the immunopathogenesis
of multiple sclerosis (MS), though the mechanisms are not yet fully understood. CD16 is a …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
leading to demyelination and axonal/neuronal loss. Cumulating evidence points to a key …

With the discovery that the highly effective anti-CD20 antibody therapies developed to
deplete CD20+ B cells deplete CD20+ T cells equally well, a great interest in the biological …

Multiple lines of evidence suggest that CD4+ lymphocytes initiate autoimmune responses
against myelin antigens in multiple sclerosis (MS). The increased frequency of activated …

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is
believed to be immune-mediated. While CD4+ T cells have been the main suspects for …

Multiple sclerosis (MS) is the most common human demyelinating disease of the central
nervous system. It is universally accepted that the immune system plays a major role in the …