Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses
Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage
of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu …
of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu …
Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
D Sauter, M Schindler, A Specht, WN Landford… - Cell host & …, 2009 - cell.com
Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …
human tetherin to promote viral release and replication. We show that Vpus from SIVgsn …
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
B Jia, R Serra-Moreno, W Neidermyer Jr… - PLoS …, 2009 - journals.plos.org
Tetherin, also known as BST2, CD317 or HM1. 24, was recently identified as an interferon-
inducible host–cell factor that interferes with the detachment of virus particles from infected …
inducible host–cell factor that interferes with the detachment of virus particles from infected …
Anti-tetherin activities in Vpu-expressing primate lentiviruses
SJ Yang, LA Lopez, H Hauser, CM Exline, KG Haworth… - Retrovirology, 2010 - Springer
Background The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …
observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected …
Nef proteins from simian immunodeficiency viruses are tetherin antagonists
Summary The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other
enveloped viruses by inducing tethering of nascent particles to infected cell surfaces. The …
enveloped viruses by inducing tethering of nascent particles to infected cell surfaces. The …
Lack of adaptation to human tetherin in HIV-1 group O and P
SJ Yang, LA Lopez, CM Exline, KG Haworth… - Retrovirology, 2011 - Springer
Background HIV-1 viruses are categorized into four distinct groups: M, N, O and P. Despite
the same genomic organization, only the group M viruses are responsible for the world-wide …
the same genomic organization, only the group M viruses are responsible for the world-wide …
Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility
T Kobayashi, H Ode, T Yoshida, K Sato, P Gee… - Journal of …, 2011 - Am Soc Microbiol
Tetherin, also known as BST-2/CD317/HM1. 24, is an antiviral cellular protein that inhibits
the release of HIV-1 particles from infected cells. HIV-1 viral protein U (Vpu) is a specific …
the release of HIV-1 particles from infected cells. HIV-1 viral protein U (Vpu) is a specific …
Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host
N Götz, D Sauter, SM Usmani, JV Fritz, C Goffinet… - Cell host & …, 2012 - cell.com
The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission
from primates to humans. After cross-species transmission, the chimpanzee precursor of …
from primates to humans. After cross-species transmission, the chimpanzee precursor of …
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants
MW McNatt, T Zang, T Hatziioannou, M Bartlett… - PLoS …, 2009 - journals.plos.org
Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of
nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein …
nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein …
Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein
D Sauter, D Unterweger, M Vogl, SM Usmani… - PLoS …, 2012 - journals.plos.org
HIV-1 groups M and N emerged within the last century following two independent cross-
species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic …
species transmissions of SIVcpz from chimpanzees to humans. In contrast to pandemic …