Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease

S Navakkode, JR Gaunt, MV Pavon, VA Bansal… - Aging …, 2021 - Wiley Online Library
Clinical studies have shown that female brains are more predisposed to neurodegenerative
diseases such as Alzheimer's disease (AD), but the cellular and molecular mechanisms …

Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa: APPsi transgenic model of Alzheimer's disease

T Melnikova, DM Park, L Becker, D Lee, E Cho… - Neurobiology of …, 2016 - Elsevier
Sex differences are a well-known phenomenon in Alzheimer's disease (AD), with women
having a higher risk for AD than men. Many AD mouse models display a similar sex …

Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

RP Kommaddi, A Verma, G Muniz-Terrera… - Translational …, 2023 - nature.com
Women carry a higher burden of Alzheimer's disease (AD) compared to men, which is not
accounted entirely by differences in lifespan. To identify the mechanisms underlying this …

Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens

YT Hu, XL Chen, YN Zhang, H McGurran… - Frontiers in …, 2023 - frontiersin.org
Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …

Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease

K Richetin, P Petsophonsakul, L Roybon, BP Guiard… - Neurobiology of …, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
memory loss and impaired cognitive functions. The higher incidence of AD among women …

Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats

O Chaudry, K Ndukwe, L Xie, M Figueiredo-Pereira… - Scientific Reports, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is most prevalent
in females. While estrogen provides neuroprotection in females, sex mediated differences in …

Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice

D Arsenault, C Tremblay, V Emond, F Calon - Biology of sex Differences, 2020 - Springer
While the higher prevalence of Alzheimer's disease (AD) in women is clear, studies suggest
that biological sex may also influence AD pathogenesis. However, mechanisms behind …

Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease

C Bories, MJ Guitton, C Julien, C Tremblay, M Vandal… - 2012 - journals.plos.org
Besides memory deficits, Alzheimer's disease (AD) patients suffer from neuropsychiatric
symptoms, including alterations in social interactions, which are subject of a growing …

[HTML][HTML] Age, sex and Alzheimer's disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in …

AJ Barber, CL Del Genio, AB Swain… - Alzheimer's …, 2024 - alzres.biomedcentral.com
Aging and sex are major risk factors for developing late-onset Alzheimer's disease.
Compared to men, women experience worse neuropathological burden and cognitive …

Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice

L Scott, J Feng, T Kiss, E Needle, K Atchison… - Neurobiology of …, 2012 - Elsevier
Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque
formation reflecting Alzheimer's disease pathology. In our study hippocampal network …