Dopaminergic neurotransmission dysfunction induced by amyloid-β transforms cortical long-term potentiation into long-term depression and produces memory …

P Moreno-Castilla, LF Rodriguez-Duran… - Neurobiology of …, 2016 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative condition manifested by synaptic
dysfunction and memory loss, but the mechanisms underlying synaptic failure are not …

Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy

S van Duijn, RJA Nabuurs… - Journal of …, 2013 - content.iospress.com
Epidemiological studies indicate that the incidence of Alzheimer's disease (AD) is higher in
women than in men. There is evidence that changes in metabolites in the brain associated …

Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice

D Baglietto‐Vargas, Y Chen, D Suh… - Journal of …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and
other cognitive functions in the elderly. The social and financial impacts of AD are …

[HTML][HTML] Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APPSwe/PS1 mice

G Naert, S Rivest - Frontiers in cellular neuroscience, 2012 - frontiersin.org
Alzheimer's disease (AD) is characterized by a progressive memory decline and numerous
pathological abnormalities, including amyloid β (Aβ) accumulation in the brain and synaptic …

Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease

ER Rosario, JC Carroll, S Oddo… - Journal of …, 2006 - Soc Neuroscience
Normal age-related testosterone depletion in men is a recently identified risk factor for
Alzheimer's disease (AD), but how androgen loss affects the development of AD is unclear …

[HTML][HTML] Differences in synaptic dysfunction between rTg4510 and APP/PS1 mouse models of Alzheimer's disease

S Gelman, J Palma, G Tombaugh… - Journal of Alzheimer's …, 2018 - content.iospress.com
Genetically modified mice have provided insights into the progression and pathology of
Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 …

[HTML][HTML] Astrocyte function is affected by aging and not Alzheimer's disease: A preliminary investigation in hippocampi of 3xTg-AD mice

MR Bronzuoli, R Facchinetti, M Valenza… - Frontiers in …, 2019 - frontiersin.org
Old age is a risk factor for Alzheimer's disease (AD), which is characterized by hippocampal
impairment together with substantial changes in glial cell functions. Are these alterations …

Sex differences in Alzheimer's disease: Understanding the molecular impact

CA Toro, L Zhang, J Cao, D Cai - Brain research, 2019 - Elsevier
Alzheimer's disease (AD) is a common neurodegenerative disorder that presents with
cognitive impairment and behavioral disturbance. Approximately 5.5 million people in the …

Sexual dimorphism in predisposition to Alzheimer's disease

DW Fisher, DA Bennett, H Dong - Neurobiology of aging, 2018 - Elsevier
Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

[HTML][HTML] Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

TVV Nguyen, M Hayes, JC Zbesko, JB Frye… - Acta neuropathologica …, 2018 - Springer
The goal of this study was to determine the chronic impact of stroke on the manifestation of
Alzheimer's disease (AD) related pathology and behavioral impairments in mice. To …