Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

Hypoxia-inducible factor (HIF) is a central regulator involved in detection and adaption to
cellular oxygen stress through regulation of the hypoxic transcriptional program in …

Hypoxia inducible factor (HIF) is an oxygen-sensitive transcription factor that enables
aerobic organisms to adapt to hypoxia. This is achieved through the transcriptional …

Abstract Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master
regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

Hypoxia-inducible factor-1 (HIF-1) is a nuclear transcription factor that is upregulated in
hypoxia and coordinates the adaptive response to hypoxia by driving the expression of over …

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Abstract Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen
homeostasis that regulate the expression of thousands of genes in order to match O2 supply …

Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …