The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

The mechanisms that regulate angiogenesis in hypoxia or hypoxic microenvironment are
modulated by several pro-and antiangiogenic factors. Hypoxia-inducible factors (HIFs) have …

Tissue hypoxia is a pathologic feature of many human diseases including cancer,
myocardial infarction, stroke, and kidney disease. An evolutionarily conserved oxygen …

Summary Hypoxia-inducible factor (HIF)-1α and HIF-2α promote cellular adaptation to acute
hypoxia, but during prolonged activation, these isoforms exert mutually antagonistic effects …

Hypoxia-inducible factor-1α (HIF-1α) is widely distributed in human cells, and it can form
different signaling pathways with various upstream and downstream proteins, mediate …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

The α/β-heterodimeric transcription factor hypoxia-inducible factor (HIF) functions when the
oxygen level in tissues is low, ie when the tissue microenvironment becomes hypoxic, and is …

Hypoxia-inducible factor (HIF) is an oxygen-dependent transcription factor that activates a
diverse set of target genes, the products of which are involved in adaptive processes to …

Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …