Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of
adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the …

Sensing and responding to fluxes in oxygen tension is perhaps the single most important
variable in physiology, and animal tissues have developed a number of essential …

Hypoxia‐inducible factors (HIFs) are transcription factors that activate the transcription of
genes necessary to circumvent to hypoxic (low oxygen level) environments. In …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master
regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory …

Hypoxia‐inducible transcription factors (HIF) mediate complex adaptations to reduced
oxygen supply, including neoangiogenesis. Regulation of HIF occurs mainly through oxygen …

Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Hypoxia inducible factor-1 (HIF-1) is a transcriptional factor responsible for cellular and
tissue adaption to low oxygen tension. HIF-1, a heterodimer consisting of a constitutively …

Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can
subsequently culminate in right heart failure and premature death. Emerging evidence …