Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis
and cancer are rising across the world. At present, pharmacologic approaches to effectively …

Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the
tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response …

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor for responses to low oxygen.
Different nonhypoxic stimuli, including hormones and growth factors, are also important HIF …

Hypoxia acts as an important regulator of physiological and pathological processes.
Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to …

Role of hypoxia in the pathogenesis of renal disease The kidney shows a remarkable
discrepancy between blood supply and oxygenation. Despite high blood flow and oxygen …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Hypoxia-inducible factor (HIF) is a main heterodimeric transcription factor that regulates the
cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia …

In most cell types a family of transcriptional regulatory proteins termed hypoxia-inducible
factors, of which HIF-1 is the most prevalent, mediates the physiologic response to hypoxia …

Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …

Hypoxia-inducible factors (HIFs) regulate the transcription of genes that mediate the
response to hypoxia. HIFs are constantly expressed and degraded under normoxia, but …