The relationship between B cells and CD4 T cells has been carefully studied, revealing a
collaborative effort in which B cells promote the activation, differentiation, and expansion of …

Activation of CD4 T cells by B cells has been extensively studied, but B cell-regulated
priming, proliferation, and survival of CD8 T cells remains controversial. B cells express high …

We show that the in vivo generation of cytokine-producing CD4 T cells specific for a given
major histocompatibility class-II (MHCII)-binding peptide of hen egg lysozyme (HEL) is …

CD4 T cell help for B cells is critical for effective Ab responses. Although many of the
molecules involved in helper functions of naive CD4 T cells have been characterized, much …

Our previous in vivo studies show that both the amount of Ag and the number of available
naive CD4 T cells affect the Th1/Th2 phenotype of the effector CD4 T cells generated. We …

CD4 T cell memory generation is shaped by a number of factors, including the strength and
duration of TCR signaling, as well as the priming environment, all of which can be modified …

The diversity of B cell subsets and their contribution to vaccine-induced immunity in humans
are not well elucidated but hold important implications for rational vaccine design. Prior …

Memory CD8 T cells acquire effector memory cell properties after reinfection and may reach
terminally differentiated, senescent states (“Hayflick limit”) after multiple infections. The …

Co-stimulatory signals are absolutely required for T cell activation after TCR–MHC-peptide
interaction. The most important co-stimulatory signal known so far is mediated by the …

Whereas the role of CD4 T cells in B cell memory generation is well established and
unequivocal, the role that CD4 T cells play in CD8 responses was until recently far more …