[HTML][HTML] The integrated landscape of causal genes and pathways in schizophrenia
C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …
robust association with schizophrenia risk. However, due to the complexity of linkage …
[HTML][HTML] Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia
With the recent success of genome-wide association studies (GWAS), a wealth of
association data has been accomplished for more than 200 complex diseases/traits …
association data has been accomplished for more than 200 complex diseases/traits …
[HTML][HTML] Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
CP Yang, X Li, Y Wu, Q Shen, Y Zeng, Q Xiong… - Nature …, 2018 - nature.com
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
strong associations with schizophrenia. However, pinpointing the potential causal genes at …
Functional genomics identify a regulatory risk variation rs4420550 in the 16p11. 2 schizophrenia-associated locus
H Chang, X Cai, HJ Li, WP Liu, LJ Zhao, CY Zhang… - Biological …, 2021 - Elsevier
Background Genome-wide association studies (GWASs) have reported hundreds of
genomic loci associated with schizophrenia, yet identifying the functional risk variations is a …
genomic loci associated with schizophrenia, yet identifying the functional risk variations is a …
[HTML][HTML] Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk
Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …
[HTML][HTML] Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia
J Liu, S Li, X Li, W Li, Y Yang, S Guo, L Lv, X Xiao… - BMC medicine, 2021 - Springer
Background Over 200 schizophrenia risk loci have been identified by genome-wide
association studies (GWASs). However, the majority of risk loci were identified in …
association studies (GWASs). However, the majority of risk loci were identified in …
[HTML][HTML] Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …
Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-
wide association studies (GWAS) have identified many schizophrenia-associated common …
wide association studies (GWAS) have identified many schizophrenia-associated common …
Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling
D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
[HTML][HTML] Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia
Background While hybridization based analysis of the cortical transcriptome has provided
important insight into the neuropathology of schizophrenia, it represents a restricted view of …
important insight into the neuropathology of schizophrenia, it represents a restricted view of …