The effects of environmental insults on human health are a major global concern. Some of
the most noxious pollutants that humans are exposed to include ozone (O3), particulate …

Hydroxynonenal (4-HNE) is a lipid peroxidation end product generated in response to
oxidative stress in the skin. Keratinocytes contain an array of antioxidant enzymes which …

Recent studies indicate that 4‐hydroxy‐trans‐2‐nonenal (HNE), a major oxidative stress
triggered lipid peroxidation‐derived aldehyde, plays a critical role in the pathophysiology of …

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Keratinocytes are potential targets of lipid peroxidation products (α, β‐unsaturated
aldehydes) generated in the skin following UV exposure, among which the most abundant …

Hydroxy-trans-2-nonenal (HNE), an α, β-unsaturated aldehyde generated endogenously by
the radical-mediated peroxidation of ω-6 polyunsaturated fatty acids, is a bioactive molecule …

Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …

Reactive intermediates produced during oxidative stress are believed to contribute to the
development and progression of a variety of age-related diseases. 4-Hydroxy-2-nonenal …

Metastable aldehydes produced by lipid peroxidation act as' toxic second messengers' that
extend the injurious potential of free radicals. 4-hydroxy 2-nonenal (HNE), a highly toxic and …

hydroxy-2-nonenal (HNE) is a α, β-unsaturated hydroxyalkenal generated by peroxidation of
n-6 polyunsaturated fatty acid. This reactive carbonyl compound exhibits a huge number of …