In this study, the reactions of N-acetyl-L-methionine (AcMet) with [{trans-PtCl (NH 3) 2} 2-μ-H
2 N (CH 2) 6 NH 2](NO 3) 2 (BBR3005: 1, 1/t, t 1) and its cis analog [{cis-PtCl (NH 3) 2} 2-μ …

Thioether binding mediates monofunctional platinum antitumor reagents to trans
configuration in DNA interactions - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC01408G …

In order to shed light on the mechanism that underlies activity of bifunctional mononuclear Pt
II analogs of transplatin we examined in the present work a DNA binding mode of the analog …

The present model study explores the chemistry of methionine complexes and ternary
methionine-guanine adducts formed by trans-[PtCl 2 (NH 3) 2](1) and antitumor trans-[PtCl 2 …

A dinuclear platinum (II) complex that was recently investigated in our group was tested for
its cytostatic activity and found to be active against HeLa S3 cells. The complex consists of a …

Polynuclear platinum compounds comprise a unique class of anticancer agents with
chemical and biological properties different from mononuclear platinum drugs. The lead …

A series of 32 cationic platinum (II) complexes of the form cis-[PtA2 (Am) Cl]+, where A is a
monodentate (NH3 or t-PrNH2) or A2 is a bidentate (ethylenediamine or 1, 2 …

The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear
bisplatinum complexes. To understand the molecular mechanisms underlying the biological …

The multinuclear (1H, 15N, 31P and 195Pt) NMR spectroscopies, ES-MS and HPLC have
been employed to investigate the structure–activity relationship for the reactions between …

Water soluble platinum (II) complexes have been synthesized that contain the N, O-chelate
pyridin-2-yl acetate (PyAc) as a novel structural motif in platinum antitumor complexes. The …