A randomized trial on the effect of phosphate reduction on vascular end points in CKD (IMPROVE-CKD)
ND Toussaint, E Pedagogos, NM Lioufas… - Journal of the …, 2020 - journals.lww.com
Background Hyperphosphatemia is associated with increased fibroblast growth factor 23
(FGF23), arterial calcification, and cardiovascular mortality. Effects of phosphate-lowering …
(FGF23), arterial calcification, and cardiovascular mortality. Effects of phosphate-lowering …
Phosphate and cardiovascular disease
J Kendrick, B Kestenbaum, M Chonchol - Advances in chronic kidney …, 2011 - Elsevier
Hyperphosphatemia is a major risk factor for death, CVE, and vascular calcification among
patients with and without kidney disease. Even serum phosphate levels within the “normal …
patients with and without kidney disease. Even serum phosphate levels within the “normal …
[HTML][HTML] Phosphate and cardiovascular disease beyond chronic kidney disease and vascular calcification
S Disthabanchong - International journal of nephrology, 2018 - hindawi.com
Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal
disease, widespread vascular calcification occurs as a result of chronic phosphate load. The …
disease, widespread vascular calcification occurs as a result of chronic phosphate load. The …
Effects of nicotinamide and lanthanum carbonate on serum phosphate and fibroblast growth factor-23 in CKD: the COMBINE trial
Background Higher serum phosphate and fibroblast growth factor-23 (FGF23) levels may be
modifiable to prevent cardiovascular disease in CKD. Short-term studies have reported …
modifiable to prevent cardiovascular disease in CKD. Short-term studies have reported …
Aortic calcification and arterial stiffness burden in a chronic kidney disease cohort with high cardiovascular risk: baseline characteristics of the impact of phosphate …
NM Lioufas, E Pedagogos, CM Hawley… - American journal of …, 2020 - karger.com
Chronic kidney disease (CKD) is associated with excess cardiovascular morbidity and
mortality compared to the general population. Hyperphosphataemia, associated with …
mortality compared to the general population. Hyperphosphataemia, associated with …
Rationale and approaches to phosphate and fibroblast growth factor 23 reduction in CKD
Patients with CKD often progress to ESRD and develop cardiovascular disease (CVD), yet
available therapies only modestly improve clinical outcomes. Observational studies report …
available therapies only modestly improve clinical outcomes. Observational studies report …
Vascular Toxicity of Phosphate in Chronic Kidney Disease–Beyond Vascular Calcification–
P Gross, I Six, S Kamel, ZA Massy - Circulation Journal, 2014 - jstage.jst.go.jp
Chronic kidney disease (CKD) is characterized by high cardiovascular morbidity/mortality,
which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED) …
which is linked in part to vascular calcification (VC) and endothelial dysfunction (ED) …
Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease
ME Seifert, L De Las Fuentes, M Rothstein… - American journal of …, 2013 - karger.com
Abstract Background/Aims: Cardiovascular disease (CVD) is increased in chronic kidney
disease (CKD), and contributed to by the CKD-mineral bone disorder (CKD-MBD). CKD …
disease (CKD), and contributed to by the CKD-mineral bone disorder (CKD-MBD). CKD …
Phosphate in early chronic kidney disease: associations with clinical outcomes and a target to reduce cardiovascular risk
ND Toussaint, E Pedagogos, SJ TAN, SV Badve… - …, 2012 - Wiley Online Library
There is an intimate association between mineral and bone disorders in chronic kidney
disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population …
disease (CKD) and the extensive burden of cardiovascular disease (CVD) in this population …
Association of serum phosphate with vascular and valvular calcification in moderate CKD
KL Adeney, DS Siscovick, JH Ix… - Journal of the …, 2009 - journals.lww.com
Within the normal range, higher serum phosphate concentrations are associated with
cardiovascular events and mortality in individuals with chronic kidney disease (CKD) and in …
cardiovascular events and mortality in individuals with chronic kidney disease (CKD) and in …