Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis
and induces neuropathological changes, such as impaired neuronal integrity …

Mitochondrial dysfunction including deficits of mitophagy is seen in aging and
neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally …

Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases
such as Parkinson's disease (PD). Therapeutic strategies targeting mitochondrial …

Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

Background: Despite considerable advances in pharmacotherapy, more effective
therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as …

Clinical and preclinical interest in Type 2 diabetes (T2D)-associated cognitive dysfunction
(TDACD) has grown in recent years. However, the precise mechanisms underlying TDACD …

(1) Background: Ellagitannins are natural products occurring in pomegranate and walnuts.
They are hydrolyzed in the gut to release ellagic acid, which is further metabolized by the …

Aim Mitochondrial autophagy (mitophagy) clears damaged mitochondria and attenuates
ischemic neuronal injury. Urolithin A (Uro‐A) activates mitophagy in mammal cells and …

Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

Diabetic stress increases the production of reactive oxygen species (ROS), leading to
mitochondrial fragmentation and dysfunction. We hypothesized that ROS-sensitive TRPM2 …