There is a need to better understand biological factors that increase the risk of persistent
musculoskeletal (MSK) pain and heightened pain sensitivity. Knowing the heritability (how …

An estimated 15–50% of the population experiences pain at any given time, at great
personal and societal cost. Pain is the most common reason patients seek medical attention …

Introduction Pain constitutes a major component of the global burden of diseases. Recent
studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas …

Abstract The Human Pain Genetics Database (HPGDB) is a comprehensive variant-focused
inventory of genetic contributors to human pain. After curation, the HPGDB currently includes …

Regional (eg, low back) and widespread chronic pain disorders are common in the general
population and are known to be heritable. Recent research suggests that genetic factors …

Chronic pain is pathological, persisting beyond normal tissue healing time. Previous work
has suggested∼ 50% variation in chronic pain development is heritable. No data are …

Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in
affected individuals and are characterized by a report of pain greater than expected based …

Large individual differences in pain sensitivity present a challenge for medical diagnosis
and may be of importance for the development of chronic pain. Variance in pain sensitivity is …

Quite a few genetic polymorphisms have been identified that associate with painful medical
conditions. There is remarkable variability in the amount pain that different people …

Sensitivity to pain varies considerably between individuals and is known to be heritable.
Increased sensitivity to experimental pain is a risk factor for developing chronic pain, a …