Prenatal exposure to antiseizure medication and incidence of childhood-and adolescence-onset psychiatric disorders

JW Dreier, MH Bjørk, S Alvestad, M Gissler… - JAMA …, 2023 - jamanetwork.com
Importance Prenatal antiseizure medication (ASM) exposure has been associated with
adverse early neurodevelopment, but associations with a wider range of psychiatric end …

Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability

MH Bjørk, H Zoega, MK Leinonen, JM Cohen… - JAMA …, 2022 - jamanetwork.com
Importance Women with epilepsy frequently need antiseizure medication (ASM) to prevent
seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to …

Risk of Autism after Prenatal Topiramate, Valproate, or Lamotrigine Exposure

S Hernández-Díaz, L Straub, BT Bateman… - … England Journal of …, 2024 - Mass Medical Soc
Background Maternal use of valproate during pregnancy has been associated with an
increased risk of neurodevelopmental disorders in children. Although most studies of other …

Prenatal Exposure to Antiseizure Medications and Risk of Epilepsy in Children of Mothers With Epilepsy

JW Dreier, J Christensen, J Igland, M Gissler… - JAMA network …, 2024 - jamanetwork.com
Importance Use of valproate and certain other antiseizure medications (ASMs) in pregnancy
is associated with abnormal fetal brain development with potential long-term implications for …

Neurodevelopmental and functional outcomes following in utero exposure to antiseizure medication: a systematic review

E Honybun, E Cockle, CB Malpas, TJ O'Brien… - Neurology, 2024 - AAN Enterprises
Background and Objectives To undertake a systematic review of the available literature to
examine the relationship between prenatal antiseizure medication (ASM) exposure and …

Two-year-old cognitive outcomes in children of pregnant women with epilepsy in the maternal outcomes and neurodevelopmental effects of antiepileptic drugs study

KJ Meador, MJ Cohen, DW Loring, RC May… - JAMA …, 2021 - jamanetwork.com
Importance The neurodevelopmental risks of fetal exposure are uncertain for many
antiseizure medications (ASMs). Objective To compare children at 2 years of age who were …

Association of prenatal exposure to valproate and other antiepileptic drugs with intellectual disability and delayed childhood milestones

CA Daugaard, L Pedersen, Y Sun, JW Dreier… - JAMA network …, 2020 - jamanetwork.com
Importance There is concern about neurodevelopmental outcomes associated with prenatal
exposure to valproate and other antiepileptic drugs (AEDs) among children of mothers with …

Cognitive outcomes at age 3 years in children with fetal exposure to antiseizure medications (MONEAD study) in the USA: a prospective, observational cohort study

KJ Meador, MJ Cohen, DW Loring… - The Lancet …, 2023 - thelancet.com
Background The neurodevelopmental effects of fetal exposure to most antiseizure
medications are unclear. We aimed to investigate the effects of fetal exposure to commonly …

In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring

LF Bech, C Polcwiartek, K Kragholm… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objectives In utero exposure to antiepileptic drugs has previously been associated with
adverse outcome among offspring, but evidence on longer term milestone development …

Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs

PO Blotière, F Raguideau, A Weill, E Elefant, I Perthus… - Neurology, 2019 - AAN Enterprises
Objective To assess the association between exposure to monotherapy with 10 different
antiepileptic drugs (AEDs) during the first 2 months of pregnancy and the risk of 23 major …