[HTML][HTML] MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line

O Perdaens, P Bottemanne… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Demyelination is one of the hallmarks of multiple sclerosis (MS). While
remyelination occurs during the disease, it is incomplete from the start and strongly …

MicroRNAs in oligodendrocyte development and remyelination

C Ngo, R Kothary - Journal of Neurochemistry, 2022 - Wiley Online Library
Oligodendrocytes are the glial cells responsible for the formation of myelin around axons of
the central nervous system (CNS). Myelin is an insulating layer that allows electrical …

The emerging role of microRNAs in multiple sclerosis

A Junker, R Hohlfeld, E Meinl - Nature Reviews Neurology, 2011 - nature.com
Several hundred microRNAs (miRNAs) fine-tune the expression of approximately half of all
human genes. Recent studies have revealed that miRNA profiles in blood cells become …

MicroRNAs: novel regulators of oligodendrocyte differentiation and potential therapeutic targets in demyelination-related diseases

JS Li, ZX Yao - Molecular neurobiology, 2012 - Springer
MicroRNAs (miRNAs or miRs) are a class of endogenous small non-coding RNAs that
consist of about 22 nucleotides and play critical roles in various biological processes …

[HTML][HTML] miRNAs as emerging regulators of oligodendrocyte development and differentiation

DA Galloway, CS Moore - Frontiers in cell and developmental biology, 2016 - frontiersin.org
Chronic demyelination is a hallmark of neurological disorders such as multiple sclerosis
(MS) and several leukodystrophies. In the central nervous system (CNS), remyelination is a …

[PDF][PDF] MicroRNA-mediated control of oligodendrocyte differentiation

X Zhao, X He, X Han, Y Yu, F Ye, Y Chen, TN Hoang… - Neuron, 2010 - cell.com
MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that
control the differentiation program of specific neural cell types has been elusive. To …

In vivo silencing of miR‐125a‐3p promotes myelin repair in models of white matter demyelination

D Marangon, E Boda, R Parolisi, C Negri, C Giorgi… - Glia, 2020 - Wiley Online Library
In the last decade, microRNAs have been increasingly recognized as key modulators of glial
development. Recently, we identified miR‐125a‐3p as a new player in oligodendrocyte …

[HTML][HTML] Regulation of miRNA 219 and miRNA Clusters 338 and 17-92 in Oligodendrocytes

O de Faria Jr, QL Cui, JM Bin, SJ Bull… - Frontiers in …, 2012 - frontiersin.org
MicroRNAs (miRs) regulate diverse molecular and cellular processes including
oligodendrocyte (OL) precursor cell (OPC) proliferation and differentiation in rodents …

Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes

P Lau, JD Verrier, JA Nielsen, KR Johnson… - Journal of …, 2008 - Soc Neuroscience
MicroRNAs (miRNAs) play important roles in modulating gene expression at the
posttranscriptional level. In postnatal oligodendrocyte lineage cells, the miRNA expression …

MicroRNA: key regulators of oligodendrocyte development and pathobiology

JMK Fitzpatrick, RC Anderson… - The International Journal of …, 2015 - Elsevier
MicroRNAs (miRNAs or miRs) are a group of small non-coding RNAs that function through
binding to messenger RNA (mRNA) targets and downregulating gene expression. miRNAs …