Addiction is a disorder of behavioral control and learning. While this may reflect pre-existing
propensities, drug use also clearly contributes by causing changes in outcome processing in …

Addiction is characterized by persistent drug-seeking despite adverse consequences or
outcomes. Such persistent behavior may result from drug-induced brain changes that …

Cocaine dependence impacts drug-related, dopamine-dependent reward processing, yet its
influence on non-drug reward processing is unclear. Here, we investigated cocaine …

Background Prominent neurobiological theories of addiction posit a central role for aberrant
mesolimbic dopamine release but disagree as to whether repeated drug experience blunts …

The nucleus accumbens core (NAc) is important for integrating and providing information to
downstream areas about the timing and value of anticipated reward. Although NAc is one of …

Dorsal lateral striatum (DLS) is a highly associative structure that encodes relationships
among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known …

Although maladaptive decision-making is a defining feature of drug abuse and addiction, we
have yet to ascertain how cocaine self-administration disrupts neural signals in anterior …

Rats trained to perform a version of the rat gambling task (rGT) in which salient audiovisual
cues accompany reward delivery, similar to commercial gambling products, show greater …

Drug-associated cues have profound effects on an addict's emotional state and drug-
seeking behavior. Although this influence must involve the motivational neural system that …

There is a compelling evidence that midbrain dopamine (DA) neurons and their projections
to the ventral striatum provide a mechanism for motivating reward‐seeking behavior, and for …