Long-term high-fat diet (HFD) consumption commonly leads to obesity, a major health
concern of western societies and a risk factor for Alzheimer's disease (AD). Both conditions …

Recent investigations have demonstrated an important role of gut microbiota (GM) in the
pathogenesis of Alzheimer's disease (AD). GM modulates a host's health and disease by …

Neuropsychiatric disorders have been one of the worldwide health problems contributing to
profound social and economic consequences. It is reported that consumption of an …

The excessive intake of a high-fat diet (HFD) leads to obesity, including metabolic
syndromes, disturbs gut microbiota composition, causes colitis, and increases the plasma …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

As the global population ages, and rates of dementia rise, understanding lifestyle factors that
play a role in the development and acceleration of cognitive decline is vital to creating …

High-fat diet (HFD) has been shown to accelerate Alzheimer's disease (AD) pathology, but
the exact molecular and cellular mechanisms remain incompletely understood. Moreover, it …

Aging and age-related diseases are associated with cellular stress, metabolic imbalance,
oxidative stress, and neuroinflammation, accompanied by cognitive impairment. Lifestyle …

Background: Normal aging is accompanied by cognitive deficiencies, affecting women and
men equally. Aging is the main risk factor for Alzheimer's disease (AD), with women having a …

Ageing is characterised by a progressive increase in systemic inflammation and especially
neuroinflammation. Neuroinflammation is associated with altered brain states that affect …