A novel role for estrogen-induced signaling in the colorectal cancer gender bias

AA Haziman, S Ravinderan, T Thangavelu… - Irish Journal of Medical …, 2019 - Springer
Colorectal cancer (CRC) is a malignancy whose incidence is increasing globally, and there
is a gender difference in the increasing risk. Evidence from hormone replacement therapy …

[HTML][HTML] Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression

JH Lin, T Morikawa, AT Chan, A Kuchiba, K Shima… - Cancer research, 2012 - AACR
Experimental studies have shown that estrogen-or progesterone-activated signaling leads to
growth inhibition effects on colon cancer cells through the upregulation of several cell-cycle …

[HTML][HTML] Sex Differences in Colon Cancer: Genomic and Nongenomic Signalling of Oestrogen

BJ Harvey, HM Harvey - Genes, 2023 - mdpi.com
Colon cancer (CRC) is a prevalent malignancy that exhibits distinct differences in incidence,
prognosis, and treatment responses between males and females. These disparities have …

[HTML][HTML] Reproductive factors, hormones and colorectal cancer—still unresolved

G Rennert - British Journal of Cancer, 2017 - nature.com
Differences in morbidity rates between males and females have been reported for many
cancer sites. Specifically, in the colon, cancers in females are more commonly detected in …

[HTML][HTML] GPER Agonist G1 Prevents Wnt-Induced JUN Upregulation in HT29 Colorectal Cancer Cells

M Abancens, BJ Harvey, J McBryan - International Journal of Molecular …, 2022 - mdpi.com
Women consistently show lower incidence and mortality rates for colorectal cancer (CRC)
compared to men. Epidemiological evidence supports a pivotal role for estrogen in …

[HTML][HTML] Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies

Y Rodríguez-Santiago, CA Garay-Canales… - Biology of Sex …, 2024 - Springer
Introduction Sexual dimorphism significantly influences cancer incidence and prognosis.
Notably, females exhibit a lower risk and favorable prognosis for non-reproductive cancers …

Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer

JH Koo, RWL Leong - Journal of gastroenterology and …, 2010 - Wiley Online Library
Sex significantly influences the clinical and pathological characteristics of colorectal cancer
(CRC). These include differences in incidence and mortality rates, clinical presentations …

[PDF][PDF] Sex-dependent regulation of estrogen receptor beta in human colorectal cancer tissue and its relationship with clock genes and VEGF-A expression

I Herichova, R Reis, K Hasakova, M Vician, M Zeman - Physiol. Res, 2019 - biomed.cas.cz
The incidence of colorectal cancer (CRC) shows a sex-dependent difference in humans.
The aim of this study was to analyze estrogen receptor β mRNA (ERβ) expression in patients …

Sex Difference of Colorectal Cancer

N Kim - Sex/Gender-Specific Medicine in the Gastrointestinal …, 2022 - Springer
Colorectal cancer (CRC) is one of the most common causes of cancer morbidity in both male
and female. The development of CRC is found 1.5 times higher in men compared to women …