Microcirculation and macrocirculation are tightly interconnected into a dangerous cross-link
in hypertension. Small artery damage includes functional (vasoconstriction, impaired …

Abstract Changes in vascular structure that accompany hypertension may contribute to
hypertensive end-organ damage. Both the macrovascular and microvascular levels should …

Large conduit arteries and the microcirculation participate in the mechanisms of elevation of
blood pressure (BP). Large vessels play roles predominantly in older subjects, with stiffening …

Hypertension is a multifactorial systemic chronic disorder through functional and structural
macrovascular and microvascular alterations. Macrovascular alterations are featured by …

Pathophysiological studies have extensively investigated the structural factor in
hypertension, including large and small artery remodeling and functional changes. Here, we …

The increased peripheral resistance in hypertension results from arteriolar vasoconstriction,
increased media-to-lumen (M/L) ratio of small resistance arteries, and rarefaction (reduction …

In hypertension, an increased media-to-lumen ratio of small resistance arteries might play
an important role in the increase of vascular resistance, and may also be an adaptive …

Structural and functional dysfunction in both the macro-and microvasculature are a feature of
essential hypertension. In a healthy cardiovascular system, the elastic properties of the large …

Hypertension is known to be associated with an increase in the wall/lumen ratio (W/L) of the
resistance arteries. Growth, eutrophic remodelling and changes in arterial distensibility can …

Raised arterial pressure not only is a clearly established risk factor for cardiovascular
events, it also accelerates the development of organ failure in diabetes and many causes of …