Development proceeds by the activation of genes by transcription factors and the
inactivation of others by chromatin-mediated gene silencing. In certain cases development …

Polycomb complexes regulate cell type–specific gene expression programs through
heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is …

The chromatin of animal cells contains two types of histones: canonical histones that are
expressed during S phase of the cell cycle to package the newly replicated genome, and …

Background Recurrent specific mutations in evolutionarily conserved histone 3 (H3) variants
drive pediatric high-grade gliomas (HGGs), but little is known about their downstream …

Trimethylation of histone H3 lysine 27 (H3K27me3) by Polycomb repressive complex 2
(PRC2) is essential for transcriptional silencing of Polycomb target genes, whereas …

Trimethylation at histone H3K27 is central to the polycomb repression system. Juxtaposed to
H3K27 is a widely conserved phosphorylatable serine residue (H3S28) whose function is …

Trimethylation of histone H3 at lysine 27 (H3-K27me3) by Polycomb repressive complex 2
(PRC2) is a key step for transcriptional repression by the Polycomb system. Demethylation …

Cell fate depends on genetic, epigenetic and environmental inputs that are interconnected,
making it difficult to disentangle their respective contributions to cell fate decisions-, and …

Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly
aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic …

Cancer is both a genetic and an epigenetic disease. Inactivation of tumour-suppressor
genes by epigenetic changes is frequently observed in human cancers, particularly as a …