The ability of a chemical to induce mutations has long been a driver in the cancer risk
assessment process. The default strategy has been that mutagenic chemicals demonstrate …

Current regulatory practices for chemical carcinogens were established when scientific
understanding of the molecular mechanisms of chemical carcinogenesis was in its infancy …

The debate on thresholds in dose–response relationships for chemical carcinogenesis
concentrates on the question of mechanisms of action that come into play only at dose levels …

It has been known for decades that mutagenicity plays an important role in the activity of
most carcinogens. This mutagenicity can result from direct damage to DNA through a …

Under the new US Environmental Protection Agency (EPA) Cancer Risk Assessment
Guidelines [US EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P …

The default assumption for risk assessment of DNA-reactive carcinogens is that exposure to
even very small amounts may result in additional risk. While this low-dose linearity has often …

Tremendous advances have been made in the study of biomarkers related to
carcinogenesis during the past 20 years. This perspective will briefly review improvements …

The determination of whether a chemical induces cancer through a mutagenic or genotoxic
mechanism frequently plays an important role in evaluating the risks associated with low …

Advances in experimental modeling of the mutational signatures of environmental
exposures and endogenous mutagenic processes will elucidate the role of mutagenesis in …

The correlation between mutagenicity and carcinogenicity has been a major approach in
genetic toxicology. Although the critical importance of changes in DNA in cancer induction is …