DNA adducts have been investigated extensively during the past decade. This research has
been advanced, in part, by the development of ultrasensitive analytical methods, such as …

This paper discusses the various methods with which occupational exposure to mutagens
and carcinogens can be biomonitored at the molecular level, and the (potential) value of …

In regulatory toxicology, it is assumed that genotoxic carcinogens, which induce cancer
through genotoxic mechanisms, have no threshold for their action. However, humans …

During the past three years two collaborative studies were started in the United States and
Japan to study the correlation between carcinogenic and mutagenic activity. New …

This is the second of two reports from the International Workshops on Genotoxicity Testing
(IWGT) Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment …

Over 50 years, we have learned a great deal about the biology that underpins cancer but our
approach to testing chemicals for carcinogenic potential has not kept up. Only a small …

Cancer is a dread disease worldwide. Mortality of individuals suffering from cancer is high,
despite the current improved methods of precocious detection, surgery and therapy …

Past attempts to correlate carcinogenic potencies of chemicals with potencies in causing
mutations or other endpoints in short-term genotoxicity tests have found quantitative …

The controversial arguments about the existence of “thresholds” for carcinogens are
discussed and some conclusions are drawn:(1) The meaning of “threshold” has changed …

At the 4th International Workshop on Genotoxicity Testing (IWGT) held on September 9–10,
2005 at San Francisco, USA, about 180 participants from government, industry and …