In December 2019, physicians in the Chinese city of Wuhan were treating patients infected
by a novel virus, now known as SARS-CoV-2. This virus caused a new influenza-like …

Around 80 representatives from the pharmaceutical industry, government and academic
institutions met for 2 days in April 2011 to discuss repurposing and rescue efforts for old and …

Abstract Purpose of Review Drug development has evolved over the years from being one-
at-a-time to be massive screens in an industrial manner. Bringing a new therapeutic agent …

Obesity is associated with up-or downregulation of certain gene products relative to the
levels seen in individuals with a normal body weight, and blood levels for many of these …

Despite an urgent need for real-world solutions such as new therapies for a host of
neglected diseases, the “impact” of academic research in the biomedical sciences is to a …

The process of developing drugs de novo is extensive, laborious, expensive, and time
consuming. Estimates for the transition of a potential therapeutic molecule to an approved …

Editorial Above 90% of lead molecules first tested in phase I studies often fails to reach the
market. Many thousands of compounds do not even complete clinical trials, which further …

Congress is expected to pass legislation regarding follow-on versions of biologics in 2009.
These pathbreaking drugs to treat cancer and other diseases are extremely complex and …

Since decades classical drug discovery is an efficacy crisis [1]. Drug repurposing has
substantial potential, simply because it is faster and cheaper to reach patient benefit. So far …