Drug-associated cues can acquire powerful motivational control over the behavior of
addicts, and can contribute to relapse via multiple, dissociable mechanisms. Most preclinical …

Cocaine addiction is characterized by long-lasting vulnerability to relapse arising because
neutral environmental stimuli become associated with drug use and then act as cues that …

Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse.
However, relapse typically occurs after abstinence rather than explicit extinction training. We …

Background Prominent neurobiological theories of addiction posit a central role for aberrant
mesolimbic dopamine release but disagree as to whether repeated drug experience blunts …

Chronic exposure to drugs of abuse is linked to long-lasting alterations in the function of
limbic system structures, including the nucleus accumbens (NAc). Although cocaine acts via …

Addiction is characterized by a high propensity for relapse, in part because cues associated
with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive …

Craving elicited by drug-associated cues intensifies across protracted drug abstinence–a
phenomenon termed “incubation of craving”–and drug-craving in human addicts correlates …

In drug addiction, cues previously associated with drug use can produce craving and
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …

Drug addiction is marked by pathological drug seeking and intense drug craving, particularly
in response to drug-related stimuli. Repeated psychostimulant administration is known to …

Background Drug cues recruit prelimbic cortex neurons that project to ipsilateral nucleus
accumbens core. However, it is not known if the same is true for prelimbic cortex projections …