Chronic stress which is common in the current society can be harmful to female reproduction
and is associated with oocyte defects. However, the underlying mechanisms remain largely …

With increase in women's age, the reproductive capability of female mammals decreases
dramatically caused by age-related oxidative stress, coinciding with the decline in the …

Embryo cryopreservation remains an important technique to enhance the reconstitution and
distribution of animal populations with high genetic merit. One of the major detrimental …

Objective This study examined the in vitro effect of melatonin on the protein synthesis of
mitochondria, as well as autophagy in matured oocytes of aged mice. Materials and …

Cryopreservation causes cryoinjury to oocytes and impairs their developmental
competence. Melatonin (MLT) can improve the effect of cryopreservation in animal oocytes …

When a defect occurs in the in vitro development of a pronuclear embryo, the interruption of
the subsequent implantation limits the success of assisted conception. This common …

Mitochondria in oocytes play important roles in many processes, including early embryo
development. Promotion of mitochondrial degradation and biogenesis through Sirtuin 1 …

Previous studies have shown that melatonin (MT) can ameliorate vitrification-inflicted
damage in mouse germinal vesicle (GV) oocytes, however, the key mechanistic basis of this …

Vitrification of oocytes has been shown to be closely associated with increased levels of
reactive oxygen species (ROS) and apoptotic events. However, little information is available …

Simple Summary Exogenous melatonin has beneficial effects on improving cumulus
oophorus expansion; mitochondrial distribution; intracellular level of glutathione; and first …