The role of α adrenergic receptors in mediating the inhibitory effect of electrical brain stimulation on epileptiform activity in rat hippocampal slices

N Ahmadirad, Y Fathollahi, M Janahmadi, Z Ghasemi… - Brain Research, 2021 - Elsevier
The Inhibitory effect of electrical low-frequency stimulation (LFS) on neuronal excitability and
seizure occurrence has been indicated in experimental models, but the precise mechanism …

Alpha adrenergic receptors have role in the inhibitory effect of electrical low frequency stimulation on epileptiform activity in rats

M Rezaei, N Ahmadirad, Z Ghasemi… - International Journal …, 2023 - Taylor & Francis
Aim: Low frequency stimulation (LFS) inhibits neuronal hyperexcitability following epileptic
activity. However, knowledge about LFS'inhibitory mechanisms is lacking. Here, α1 and α2 …

Low-frequency electrical stimulation reduces the impairment in synaptic plasticity following epileptiform activity in rat hippocampal slices through α1, But Not α2 …

N Ahmadirad, Y Fathollahi, M Janahmadi, A Shojaei… - Neuroscience, 2019 - Elsevier
Low frequency stimulation (LFS) has anticonvulsant effect and may restore the ability of long-
term potentiation (LTP) to the epileptic brain. The mechanisms of LFS have not been …

The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices

Z Ghasemi, N Naderi, A Shojaei, MR Raoufy… - Brain Research, 2019 - Elsevier
Low frequency stimulation (LFS) has inhibitory effect on hyperexcitability during epileptic
states. However, knowledge is lacking about LFS patterns that can exert an optimal …

Effect of low-frequency electrical stimulation on the high-K+-induced neuronal hyperexcitability in rat hippocampal slices

Z Ghasemi, N Naderi, A Shojaei, MR Raoufy… - Neuroscience, 2018 - Elsevier
Low-frequency electrical stimulation (LFS) is a potential therapeutic method for epilepsy
treatment. However, the effect of different LFS characteristics including the number of pulses …

[HTML][HTML] Low frequency electrical stimulation attenuated the epileptiform activity-induced changes in action potential features in hippocampal CA1 pyramidal neurons

Z Ghasemi, N Naderi, A Shojaei… - Cell Journal …, 2018 - ncbi.nlm.nih.gov
Objective Electrical low frequency stimulation (LFS) is a new therapeutic method that
moderates hyperexcitability during epileptic states. Seizure occurrence is accompanied by …

Cellular mechanisms underlying antiepileptic effects of low-and high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro

Y Schiller, Y Bankirer - Journal of neurophysiology, 2007 - journals.physiology.org
Approximately 30% of epilepsy patients suffer from drug-resistant epilepsy. Direct electrical
stimulation of the epileptogenic zone is a potential new treatment modality for this …

Study on the mechanism of high-frequency stimulation inhibiting low-Mg2+-induced epileptiform discharges in juvenile rat hippocampal slices

Y Zheng, K Zhang, L Dong, C Tian - Brain Research Bulletin, 2020 - Elsevier
Study on the mechanism of high-frequency stimulation inhibiting low-Mg 2+-induced
epileptiform discharges in juvenile rat hippocampal slices High-frequency stimulation (HFS) …

Noradrenergic modulation of epileptiform activity in the hippocampus

PA Rutecki - Epilepsy research, 1995 - Elsevier
Norepinephrine has been proposed to have both pro-and anticonvulsant properties. In the
CA3 region of rat hippocampal slices, we studied the effects of norepinephrine and selective …

The antiepileptogenic effect of electrical stimulation at different low frequencies is accompanied with change in adenosine receptors gene expression in rats

A Jahanshahi, J Mirnajafi‐Zadeh, M Javan… - …, 2009 - Wiley Online Library
Purpose: Previous studies have shown that the anticonvulsant effects of low‐frequency
stimulation (LFS) can be affected by activation of adenosine receptors. In the present study …